of Work: This project includes four areas: (1) a new method of analysis for statistically dependent binary outcomes; (2) a new design for case-control studies, based on pooling of specimens for assay; (3) imputation of missingepochs for reconstruction of historical exposures; (4) regression analysis of time-to-failure when there are errors in covariates. Statistically-dependent data arise in many research contexts. In toxicology, pup-specific outcomes may be more similar for pups from the same litter than for pups from different litters, raising the """"""""litter effects"""""""" problem. When assessing effects of exposures on risk of miscarriage, pregnancy outcomes tend to be more similar among pregnancies from a given woman, because of variability in susceptibility from woman to woman. We have developed a method based on sampling one outcome per cluster, carrying out a classical analysis on these now-independent outcomes, and then repeating the resampling many times, ultimately pooling the parameter estimates. """"""""Within Cluster Resampling"""""""" (WCR) performs well in simulations, is analytically simple, and avoids the need to make ad hoc assumptions about the underlying covariance structure. A new project is related to the problem of designing case-control studies in a context where biologic specimens are available, but the assay is expensive. The """"""""Pooled Exposure Assessment"""""""" design (PEA) pools equal aliquots from randomly grouped n-tuples of cases and n-tuples of controls. Under a multiplicative model for risk, these """"""""tuples"""""""" can be analyzed to produce valid estimates of the person-based dose-response for risk. Very little statistical power is sacrificed. Savings are potentially great for a study involving an expensive assay, such as that required for measuring dioxin in serum.
| Weinberg, Clarice R (2017) Invited Commentary: Can Issues With Reproducibility in Science Be Blamed on Hypothesis Testing? Am J Epidemiol 186:636-638 |
| Lyles, Robert H; Mitchell, Emily M; Weinberg, Clarice R et al. (2016) An efficient design strategy for logistic regression using outcome- and covariate-dependent pooling of biospecimens prior to assay. Biometrics 72:965-75 |
| Lyles, Robert H; Van Domelen, Dane; Mitchell, Emily M et al. (2015) A Discriminant Function Approach to Adjust for Processing and Measurement Error When a Biomarker is Assayed in Pooled Samples. Int J Environ Res Public Health 12:14723-40 |
| Saha-Chaudhuri, Paramita; Umbach, David M; Weinberg, Clarice R (2011) Pooled exposure assessment for matched case-control studies. Epidemiology 22:704-12 |
| Weinberg, C R (2009) Less is more, except when less is less: Studying joint effects. Genomics 93:10-2 |
| Weinberg, Clarice R (2007) Can DAGs clarify effect modification? Epidemiology 18:569-72 |
| Weinberg, Clarice R; Shore, David L; Umbach, David M et al. (2007) Using risk-based sampling to enrich cohorts for endpoints, genes, and exposures. Am J Epidemiol 166:447-55 |
| Basso, Olga; Wilcox, Allen J; Weinberg, Clarice R (2006) Birth weight and mortality: causality or confounding? Am J Epidemiol 164:303-11 |
| Howards, Penelope P; Hertz-Picciotto, Irva; Weinberg, Clarice R et al. (2006) Misclassification of gestational age in the study of spontaneous abortion. Am J Epidemiol 164:1126-36 |
| Weinberg, C R (2005) Invited commentary: Barker meets Simpson. Am J Epidemiol 161:33-5; discussion 36-7 |
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