Abstract

Mean blood lead in the randomized children is 26 mg/dl: succimer produced an abrupt drop with slow rebound, and blood lead in children given succimer remain below those of the children given placebo for 6 months. Hospitalization for trauma is more frequent in the children on active drug, but there is no discernable pattern within the traumatic events. TLC had to recall its vitamin and mineral supplement because of lead contamination, but did not find any effect on lead levels from the 3 months or so during which the contaminated supplements were dispensed. All children have completed the treatment phase. Placebo-treated children had a gradual decrease in blood lead. Succimer-treated children had an abrupt drop in blood lead, followed by rebound. The mean blood lead of the succimer-treated children over the six months following initiation of treatment was 4.5 mg/dL lower than that of placebo-treated children. There were few succimer-related side effects, but there was an unanticipated excess of trauma in the succimer-treated children. In summary, succimer lowers blood lead with few side effects. Three years of developmental follow up will be completed in about March 2000.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Intramural Research (Z01)
Project #
1Z01ES043011-06
Application #
6432296
Study Section
Epidemiology and Biometry Training Committee (EB)
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst of Environ Hlth Scis
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Chen, Aimin; Cai, Bo; Dietrich, Kim N et al. (2007) Lead exposure, IQ, and behavior in urban 5- to 7-year-olds: does lead affect behavior only by lowering IQ? Pediatrics 119:e650-8
Chen, Aimin; Rhoads, George G; Cai, Bo et al. (2006) The effect of chelation on blood pressure in lead-exposed children: a randomized study. Environ Health Perspect 114:579-83
Chen, Aimin; Schwarz, Donald; Radcliffe, Jerilynn et al. (2006) Maternal IQ, child IQ, behavior, and achievement in urban 5-7 year olds. Pediatr Res 59:471-7
Harville, E W; Hertz-Picciotto, I; Schramm, M et al. (2005) Factors influencing the difference between maternal and cord blood lead. Occup Environ Med 62:263-9
Chen, Aimin; Rogan, Walter J (2005) Improving behavior of lead-exposed children: micronutrient supplementation, chelation, or prevention. J Pediatr 147:570-1
Chen, Aimin; Dietrich, Kim N; Ware, James H et al. (2005) IQ and blood lead from 2 to 7 years of age: are the effects in older children the residual of high blood lead concentrations in 2-year-olds? Environ Health Perspect 113:597-601
Peterson, Karen E; Salganik, Mikhail; Campbell, Carla et al. (2004) Effect of succimer on growth of preschool children with moderate blood lead levels. Environ Health Perspect 112:233-7
Jarosinska, Dorota; Peddada, Shyamal; Rogan, Walter J (2004) Assessment of lead exposure and associated risk factors in urban children in Silesia, Poland. Environ Res 95:133-42
Dietrich, Kim N; Ware, James H; Salganik, Mikhail et al. (2004) Effect of chelation therapy on the neuropsychological and behavioral development of lead-exposed children after school entry. Pediatrics 114:19-26
Rogan, Walter J; Ware, James H (2003) Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter. J Pediatr 143:687-8

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