Abstract

In a randomized clinical trial of succimer, an oral chelating agent that lowers blood lead concentration, children with blood leads of 20 to 44 micrograms per deciliter were given succimer or placebo when they were about 2 years old and followed with cognitive and behavioral testing. We reported previously that, despite lower blood lead levels during treatment, children given succimer had test scores that were no different from those of children given placebo at ages five or seven years. This year we used the trial data set to determine whether the effects of blood lead on behavior were direct or were mediated through the effect on IQ. We found that lead has direct effects on externalizing behavior (pushing, shouting) but not on internalizing behavior (fears, worries).? We have arranged with CDC to analyze blood samples collected in this project for mercury, which will allow a randomized trial of succimer for mercury chelation without enrolling any new subjects or collecting any specimens. We also used trial data to see if chelation therapy lowered blood pressure, which it did not.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Intramural Research (Z01)
Project #
1Z01ES043011-12
Application #
7327659
Study Section
Epidemiology and Biometry Training Committee (EB)
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
2006
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst of Environ Hlth Scis
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Chen, Aimin; Cai, Bo; Dietrich, Kim N et al. (2007) Lead exposure, IQ, and behavior in urban 5- to 7-year-olds: does lead affect behavior only by lowering IQ? Pediatrics 119:e650-8
Chen, Aimin; Rhoads, George G; Cai, Bo et al. (2006) The effect of chelation on blood pressure in lead-exposed children: a randomized study. Environ Health Perspect 114:579-83
Chen, Aimin; Schwarz, Donald; Radcliffe, Jerilynn et al. (2006) Maternal IQ, child IQ, behavior, and achievement in urban 5-7 year olds. Pediatr Res 59:471-7
Harville, E W; Hertz-Picciotto, I; Schramm, M et al. (2005) Factors influencing the difference between maternal and cord blood lead. Occup Environ Med 62:263-9
Chen, Aimin; Rogan, Walter J (2005) Improving behavior of lead-exposed children: micronutrient supplementation, chelation, or prevention. J Pediatr 147:570-1
Chen, Aimin; Dietrich, Kim N; Ware, James H et al. (2005) IQ and blood lead from 2 to 7 years of age: are the effects in older children the residual of high blood lead concentrations in 2-year-olds? Environ Health Perspect 113:597-601
Peterson, Karen E; Salganik, Mikhail; Campbell, Carla et al. (2004) Effect of succimer on growth of preschool children with moderate blood lead levels. Environ Health Perspect 112:233-7
Jarosinska, Dorota; Peddada, Shyamal; Rogan, Walter J (2004) Assessment of lead exposure and associated risk factors in urban children in Silesia, Poland. Environ Res 95:133-42
Dietrich, Kim N; Ware, James H; Salganik, Mikhail et al. (2004) Effect of chelation therapy on the neuropsychological and behavioral development of lead-exposed children after school entry. Pediatrics 114:19-26
Rogan, Walter J; Ware, James H (2003) Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter. J Pediatr 143:687-8

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