NIEHS Statistical Consulting Service

Haseman, Joseph K.

Abstract

The goal of this project is to provide statistical and computational expertise in the design, analysis, and interpretation of experimental results for a variety of Institute research activities, including both laboratory and human studies. Approximately 80 scientists made use of the Statistical Consulting Service in FY99. Many of these activities involved NTPs long term rodent carcinogenicity studies. During FY99 we provided significant input into the preparation of approximately 12 NTP Technical Reports that summarized the results of these studies. We also coauthored papers in the scientific literature dealing with the carcinogenic effects of magnetic fields, ethylbenzene, pentachlorophenol, and molybdenum trioxide. Examples of other collaborations include an assessment of the proliferative target organ effects and control tumor profiles observed in a set of NTP studies in Tg.AC transgenic and p53-heterozygous mice, two genetically altered mouse strains which are of emerging importance in toxicologic pathology. - Statistical consulting; collaborative research; experimental design; data analysis; National Toxicology Program

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Environmental Health Sciences (NIEHS)
• Type: Intramural Research (Z01)
• Project #: 1Z01ES045005-03
• Application #: 6289961
• Study Section: Special Emphasis Panel (BB)
• Support Year: 3
• Fiscal Year: 1999

Institution

• Name: National Institute of Environmental Health Sciences
• Country: United States

Publications

Garg, Ankit; Brodie, Bruce R; Stuckey, Thomas D et al. (2014) New generation drug-eluting stents for ST-elevation myocardial infarction: a new paradigm for safety. Catheter Cardiovasc Interv 84:955-62

White, Richard A; Bjørnholt, Jørgen V; Baird, Donna D et al. (2013) Novel developmental analyses identify longitudinal patterns of early gut microbiota that affect infant growth. PLoS Comput Biol 9:e1003042

Brodie, Bruce; Pokharel, Yashashwi; Garg, Ankit et al. (2012) Predictors of early, late, and very late stent thrombosis after primary percutaneous coronary intervention with bare-metal and drug-eluting stents for ST-segment elevation myocardial infarction. JACC Cardiovasc Interv 5:1043-51

Perdivara, Irina; Peddada, Shyamal D; Miller, Frederick W et al. (2011) Mass spectrometric determination of IgG subclass-specific glycosylation profiles in siblings discordant for myositis syndromes. J Proteome Res 10:2969-78

Bernstein, David I; Kissling, Grace E; Khurana Hershey, Gurjit et al. (2011) Hexamethylene diisocyanate asthma is associated with genetic polymorphisms of CD14, IL-13, and IL-4 receptor ?. J Allergy Clin Immunol 128:418-20

Brodie, Bruce; Pokharel, Yashashwi; Fleishman, Nathan et al. (2011) Very late stent thrombosis after primary percutaneous coronary intervention with bare-metal and drug-eluting stents for ST-segment elevation myocardial infarction: a 15-year single-center experience. JACC Cardiovasc Interv 4:30-8

Cullen, John M; Brown, Danielle L; Kissling, Grace E et al. (2009) Aflatoxin B1 and/or hepatitis B virus induced tumor spectrum in a genetically engineered hepatitis B virus expression and Trp53 haploinsufficient mouse model system for hepatocarcinogenesis. Toxicol Pathol 37:333-42

Keenan, Charlotte; Elmore, Susan; Francke-Carroll, Sabine et al. (2009) Potential for a global historical control database for proliferative rodent lesions. Toxicol Pathol 37:677-8

Schindler, Eva M; Hindes, Anna; Gribben, Erin L et al. (2009) p38delta Mitogen-activated protein kinase is essential for skin tumor development in mice. Cancer Res 69:4648-55

Keenan, Charlotte; Elmore, Susan; Francke-Carroll, Sabine et al. (2009) Best practices for use of historical control data of proliferative rodent lesions. Toxicol Pathol 37:679-93