Environmental Effects on Fertility

Baird, D D.

Abstract

The primary purpose of the project on fertility is to develop methods for identifying reproductive hazards. The majority of reproductive failure in women occurs before they know they are pregnant. We are currently focussing on two ways of assessing this reproductive loss. The first is development of questionnaire methods for studying fertility. We applied this method to an occupational cohort in a study of mercury vapor and nitrous oxide exposure in dental assistants. This study also allowed us to evaluate the accuracy of mail-questionnaire data on time to pregnancy, the basic data used to compare fertility among exposed and unexposed. The second approach is focussed on developing biological markers of impaired ovarian function. Estrogen and progesterone metabolites in daily urines are being measured to characterize follicular development, ovulation, and luteal function. Ultimately, we are working toward developing methods for studying reproductive hazards in small populations so that localized exposures can be evaluated.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Environmental Health Sciences (NIEHS)
• Type: Intramural Research (Z01)
• Project #: 1Z01ES049003-01
• Application #: 3876926
• Support Year: 1
• Fiscal Year: 1990

Institution

• Name: National Institute of Environmental Health Sciences
• Country: United States

Publications

Wang, Cuicui; Chen, Renjie; Shi, Min et al. (2018) Possible Mediation by Methylation in Acute Inflammation Following Personal Exposure to Fine Particulate Air Pollution. Am J Epidemiol 187:484-493

Chin, Helen B; Baird, Donna D; McConnaughey, D Robert et al. (2017) Long-term Recall of Pregnancy-related Events. Epidemiology 28:575-579

O'Brien, Katie M; Upson, Kristen; Cook, Nancy R et al. (2016) Environmental Chemicals in Urine and Blood: Improving Methods for Creatinine and Lipid Adjustment. Environ Health Perspect 124:220-7

Jukic, Anne Marie; Calafat, Antonia M; McConnaughey, D Robert et al. (2016) Urinary Concentrations of Phthalate Metabolites and Bisphenol A and Associations with Follicular-Phase Length, Luteal-Phase Length, Fecundability, and Early Pregnancy Loss. Environ Health Perspect 124:321-8

Jukic, Anne Marie Z; Steiner, Anne Z; Baird, Donna D (2015) Lower plasma 25-hydroxyvitamin D is associated with irregular menstrual cycles in a cross-sectional study. Reprod Biol Endocrinol 13:20

Jukic, Anne Marie Z; Steiner, Anne Z; Baird, Donna D (2015) Association between serum 25-hydroxyvitamin D and ovarian reserve in premenopausal women. Menopause 22:312-6

Buckley, Jessie P; Palmieri, Rachel T; Matuszewski, Jeanine M et al. (2012) Consumer product exposures associated with urinary phthalate levels in pregnant women. J Expo Sci Environ Epidemiol 22:468-75

Steiner, Anne Z; Baird, Donna D; Kesner, James S (2008) Mother's menopausal age is associated with her daughter's early follicular phase urinary follicle-stimulating hormone level. Menopause 15:940-4

Jukic, Anne Marie Zaura; Weinberg, Clarice R; Baird, Donna D et al. (2007) Lifestyle and reproductive factors associated with follicular phase length. J Womens Health (Larchmt) 16:1340-7

Nguyen, Ruby H N; Wilcox, Allen J; Baird, Donna D (2007) Can men provide accurate confounder data about their partners for Time-to-Pregnancy studies? Ann Epidemiol 17:186-90