Environmental Effects on Fertility

Baird, Donna D.

Abstract

of Work: The primary purpose of the project on fertility is to develop methods for identifying reproductive hazards. Ultimately, we are working toward developing methods for studying reproductive hazards in small populations so that localized exposures can be evaluated. First, we have developed questionnaire methods for measuring fertility using data on time to pregnancy, the number of noncontracepting menstrual cycles required to conceive. This measure can be the focus of epidemiologic studies of fertility or can be integrated into epidemiologic studies of other diseases such as breast cancer. Data on fertility has been collected in the Agricultural Health Study. These data will be available in the fall of 1999 for an analysis of pesticide related effects and fertility. Our second approach focusses on developing biological markers of impaired ovarian function. We have begun by examining urinary metabolites of estrogen and progesterone. These have been measured in daily urine specimens from over 700 menstrual cycles from about 200 women. First, we developed a method for detecting day of ovulation using these urinary hormone data. Our ability to detect ovulation using this method was very good. Now we are developing methods for characterizing follicular development, luteal function, and hormonal factors associated with conception and pregnancy loss, including rescue of the corpus luteum. - fertility, environmental effects, reproductive hazard, exposure, pesticide, ovarian function, estrogen, urinary metabolites - Human Subjects & Human Subjects: Interview, Questionaires, or Surveys Only

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Environmental Health Sciences (NIEHS)
• Type: Intramural Research (Z01)
• Project #: 1Z01ES049003-10
• Application #: 6289972
• Study Section: Special Emphasis Panel (EBMP)
• Support Year: 10
• Fiscal Year: 1999

Institution

• Name: National Institute of Environmental Health Sciences
• Country: United States

Publications

Wang, Cuicui; Chen, Renjie; Shi, Min et al. (2018) Possible Mediation by Methylation in Acute Inflammation Following Personal Exposure to Fine Particulate Air Pollution. Am J Epidemiol 187:484-493

Chin, Helen B; Baird, Donna D; McConnaughey, D Robert et al. (2017) Long-term Recall of Pregnancy-related Events. Epidemiology 28:575-579

O'Brien, Katie M; Upson, Kristen; Cook, Nancy R et al. (2016) Environmental Chemicals in Urine and Blood: Improving Methods for Creatinine and Lipid Adjustment. Environ Health Perspect 124:220-7

Jukic, Anne Marie; Calafat, Antonia M; McConnaughey, D Robert et al. (2016) Urinary Concentrations of Phthalate Metabolites and Bisphenol A and Associations with Follicular-Phase Length, Luteal-Phase Length, Fecundability, and Early Pregnancy Loss. Environ Health Perspect 124:321-8

Jukic, Anne Marie Z; Steiner, Anne Z; Baird, Donna D (2015) Lower plasma 25-hydroxyvitamin D is associated with irregular menstrual cycles in a cross-sectional study. Reprod Biol Endocrinol 13:20

Jukic, Anne Marie Z; Steiner, Anne Z; Baird, Donna D (2015) Association between serum 25-hydroxyvitamin D and ovarian reserve in premenopausal women. Menopause 22:312-6

Buckley, Jessie P; Palmieri, Rachel T; Matuszewski, Jeanine M et al. (2012) Consumer product exposures associated with urinary phthalate levels in pregnant women. J Expo Sci Environ Epidemiol 22:468-75

Steiner, Anne Z; Baird, Donna D; Kesner, James S (2008) Mother's menopausal age is associated with her daughter's early follicular phase urinary follicle-stimulating hormone level. Menopause 15:940-4

Jukic, Anne Marie Zaura; Weinberg, Clarice R; Baird, Donna D et al. (2007) Lifestyle and reproductive factors associated with follicular phase length. J Womens Health (Larchmt) 16:1340-7

Nguyen, Ruby H N; Wilcox, Allen J; Baird, Donna D (2007) Can men provide accurate confounder data about their partners for Time-to-Pregnancy studies? Ann Epidemiol 17:186-90