We have designed a case-control study to estimate the risk of uterine fibroids of >1.5 cm (as detected by a standard transabdominal and transvaginal ultrasound examination) in black women compared to nonblacks aged 35-49. Risk factors for the condition will be identified, and uterine tissue from women having fibroids removed will be studied to idenitify growth factors and genetic changes in the tissue that are associated with fibroid development. Data will be collected from 300-600 cases (both ultrasound identified and surgically identified cases of leiomyomas) and 300 controls (women found to have no evidence of leiomyomas at ultrasound) from the membership of a health care plan that serves approximately equal numbers of blacks and whites. A personal interview has been designed to provide information on demographic factors, medical history, dietary intake, reproductive history, life style factors, and occupational/environmental exposures. Blood will be collected (after fasting) in order to measure lipids, insulin, antibody titers for Chlamydia and Cytomegalovirus, endogenous gonadotropins, and potential susceptibility genes. Blood pressure, heart rate, weight, height, and waist-to-hip ratio will be measured. Medical record data will provide descriptive information on nonresponders. Tissue from surgical specimens will be analyzed for growth factors, genetic factors, and steroid receptor levels.
| Upson, Kristen; Harmon, Quaker E; Laughlin-Tommaso, Shannon K et al. (2016) Soy-based Infant Formula Feeding and Heavy Menstrual Bleeding Among Young African American Women. Epidemiology 27:716-25 |
| Dragomir, Anca D; Schroeder, Jane C; Connolly, AnnaMarie et al. (2010) Potential risk factors associated with subtypes of uterine leiomyomata. Reprod Sci 17:1029-35 |
| Vines, Anissa I; Baird, Donna D (2009) Stress of caring for children: the role of perceived racism. J Natl Med Assoc 101:156-60 |
| Jukic, Anne Marie Zaura; Weinberg, Clarice R; Baird, Donna D et al. (2008) Measuring menstrual discomfort: a comparison of interview and diary data. Epidemiology 19:846-50 |
| Baird, Donna Day; Dunson, David B; Hill, Michael C et al. (2007) Association of physical activity with development of uterine leiomyoma. Am J Epidemiol 165:157-63 |
| Baird, Donna Day; Travlos, Gregory S (2007) Obesity and insulin-like growth factor-I in African Americans and Whites. Cancer Epidemiol Biomarkers Prev 16:1526;author reply 1526 |
| Vines, Anissa I; Baird, Donna D; McNeilly, Maya et al. (2006) Social correlates of the chronic stress of perceived racism among Black women. Ethn Dis 16:101-7 |
| Baird, Donna D; Kesner, James S; Dunson, David B (2006) Luteinizing hormone in premenopausal women may stimulate uterine leiomyomata development. J Soc Gynecol Investig 13:130-5 |
| Baird, Donna Day; Newbold, Retha (2005) Prenatal diethylstilbestrol (DES) exposure is associated with uterine leiomyoma development. Reprod Toxicol 20:81-4 |
| Baird, Donna Day (2004) Invited commentary: uterine leiomyomata-we know so little but could learn so much. Am J Epidemiol 159:124-6 |
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