of Work: Diet may affect the risk of several chronic human diseases but additional research is needed. This project has two main thrusts. One is the study of diet-cancer relations; the other is the study of diet in relation to risk of amyotrophic lateral sclerosis (ALS). The diet-cancer relations under investigation are vegetable intake in relation to risk of breast cancer, studies of alcohol drinking patterns in relation to risk of breast cancer, and studies of eating frequency in relation to risk of colorectal cancer. Additional related work is listed in the list of publications. The present emphasis is on analysis of existing data resources (the National Health and Nutrition Examination Survey Epidemiologic Follow-up Study, the Cancer and Steroid Hormone Study, and other studies). Defects in antioxidant defences (e.g., superoxide dismutase 1 [SOD1]) are a cause of ALS, thus it is reasonable to suspect that antioxidant intake may also affect the incidence or progression of this disease. Regarding diet and ALS, one thrust is an analysis of dietary data from Dr. Kamel's case-control study of ALS. A second project on diet and ALS is in a developmental stage. The goal is to determine the feasibility of studying the relation in a large cohort study underway at the National Cancer Institute. The cohort consists of members of the American Association of Retired Persons (AARP) who have completed a dietary questionnaire (approximately 600,000 people). We expect about 150 cases of amyotrophic lateral sclerosis to develop in this cohort by 2002.
| Eggesbø, Merete; Thomsen, Cathrine; Jørgensen, Jens V et al. (2011) Associations between brominated flame retardants in human milk and thyroid-stimulating hormone (TSH) in neonates. Environ Res 111:737-43 |
| Ye, Xibiao; Qian, Haojun; Xu, Peicheng et al. (2009) Nephrotoxicity, neurotoxicity, and mercury exposure among children with and without dental amalgam fillings. Int J Hyg Environ Health 212:378-86 |
| Fraser, Abigail; Longnecker, Matthew P; Lawlor, Debbie A (2007) Prevalence of elevated alanine aminotransferase among US adolescents and associated factors: NHANES 1999-2004. Gastroenterology 133:1814-20 |
| Gesink Law, D C; Maclehose, R F; Longnecker, M P (2007) Obesity and time to pregnancy. Hum Reprod 22:414-20 |
| Daniels, Julie L; Rowland, Andrew S; Longnecker, Matthew P et al. (2007) Maternal dental history, child's birth outcome and early cognitive development. Paediatr Perinat Epidemiol 21:448-57 |
| Zhou, Haibo; Chen, Jianwei; Rissanen, Tiina H et al. (2007) Outcome-dependent sampling: an efficient sampling and inference procedure for studies with a continuous outcome. Epidemiology 18:461-8 |
| Zhang, Yawei; Graubard, Barry I; Longnecker, Matthew P et al. (2007) Maternal hormone levels and perinatal characteristics: implications for testicular cancer. Ann Epidemiol 17:85-92 |
| McGlynn, Katherine A; Graubard, Barry I; Klebanoff, Mark A et al. (2006) Risk factors for cryptorchism among populations at differing risks of testicular cancer. Int J Epidemiol 35:787-95 |
| Chen, Aimin; Pennell, Michael L; Klebanoff, Mark A et al. (2006) Maternal smoking during pregnancy in relation to child overweight: follow-up to age 8 years. Int J Epidemiol 35:121-30 |
| McGlynn, Katherine A; Graubard, Barry I; Nam, Jun-Mo et al. (2005) Maternal hormone levels and risk of cryptorchism among populations at high and low risk of testicular germ cell tumors. Cancer Epidemiol Biomarkers Prev 14:1732-7 |
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