Diet may affect child development, and by completely different mechanisms, the risk of several chronic diseases, but additional research is needed. This report will focus on my study of diet in relation to risk of amyotrophic lateral sclerosis (ALS). Other work in this area is reflected by my list of publications. Defects in antioxidant defenses (e.g., superoxide dismutase 1) are a cause of ALS, thus it is reasonable to suspect that antioxidant intake may also affect the incidence or progression of this disease. Results from case-control studies addressing this question, however, have been mixed. Furthermore, case-control data suggest that intake of fat, fiber, and of glutamate may alter risk. My project is an add-on to a large cohort study underway at the National Cancer Institute. The cohort consists of members of the American Association of Retired Persons (AARP) who have completed a dietary questionnaire (approximately 600,000 people). We expect about 150 cases of amyotrophic lateral sclerosis to develop in this cohort by 2004. Large, prospective studies of diet and ALS have not been done and are sorely needed. The AARP cohort was designed to look at diet and other lifestyle factors and cancer, but information on other causes of death is collected. This is an exciting opportunity to focus on non-cancer chronic diseases that are of interest to NIEHS. As a first step, and to follow-up on some of my previous work, I am venturing into the initial stages of a collaboration. Even if the hypotheses noted above turn out to be null, we will have built a bridge that can lead to excellent work on other non-cancer chronic diseases. Last year's progress: Waiting for cases of ALS to accrue has been the major activity. We began negotiations with NCI about how to verify cases of ALS, using medical records.
| Eggesbø, Merete; Thomsen, Cathrine; Jørgensen, Jens V et al. (2011) Associations between brominated flame retardants in human milk and thyroid-stimulating hormone (TSH) in neonates. Environ Res 111:737-43 |
| Ye, Xibiao; Qian, Haojun; Xu, Peicheng et al. (2009) Nephrotoxicity, neurotoxicity, and mercury exposure among children with and without dental amalgam fillings. Int J Hyg Environ Health 212:378-86 |
| Fraser, Abigail; Longnecker, Matthew P; Lawlor, Debbie A (2007) Prevalence of elevated alanine aminotransferase among US adolescents and associated factors: NHANES 1999-2004. Gastroenterology 133:1814-20 |
| Gesink Law, D C; Maclehose, R F; Longnecker, M P (2007) Obesity and time to pregnancy. Hum Reprod 22:414-20 |
| Daniels, Julie L; Rowland, Andrew S; Longnecker, Matthew P et al. (2007) Maternal dental history, child's birth outcome and early cognitive development. Paediatr Perinat Epidemiol 21:448-57 |
| Zhou, Haibo; Chen, Jianwei; Rissanen, Tiina H et al. (2007) Outcome-dependent sampling: an efficient sampling and inference procedure for studies with a continuous outcome. Epidemiology 18:461-8 |
| Zhang, Yawei; Graubard, Barry I; Longnecker, Matthew P et al. (2007) Maternal hormone levels and perinatal characteristics: implications for testicular cancer. Ann Epidemiol 17:85-92 |
| McGlynn, Katherine A; Graubard, Barry I; Klebanoff, Mark A et al. (2006) Risk factors for cryptorchism among populations at differing risks of testicular cancer. Int J Epidemiol 35:787-95 |
| Chen, Aimin; Pennell, Michael L; Klebanoff, Mark A et al. (2006) Maternal smoking during pregnancy in relation to child overweight: follow-up to age 8 years. Int J Epidemiol 35:121-30 |
| McGlynn, Katherine A; Graubard, Barry I; Nam, Jun-Mo et al. (2005) Maternal hormone levels and risk of cryptorchism among populations at high and low risk of testicular germ cell tumors. Cancer Epidemiol Biomarkers Prev 14:1732-7 |
Showing the most recent 10 out of 20 publications
