We have used the patch clamp technique to identify further intermediate molecular steps linking receptor activation by inhibitory neuropeptides to protein phosphatase stimulation, to identify a second, novel phosphorylation site on calcium- and voltage-dependent potassium channels with distinct regulation and consequences for channel function, and to identify other peptides and channels that initiate or are regulated by this pathway. In addition, we have cloned and are expressing the potassium channels and proteinphosphatases to confirm our hypotheses at the molecular level.
| Lucas, Sarah J; Armstrong, David L (2015) Protein phosphatase modulation of somatostatin receptor signaling in the mouse hippocampus. Neuropharmacology 99:232-41 |
| Chatterjee, Anindya; Wang, Ling; Armstrong, David L et al. (2010) Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitro. J Biol Chem 285:3872-82 |
| Armstrong, David L; Erxleben, Christian; White, Jody A (2010) Patch clamp methods for studying calcium channels. Methods Cell Biol 99:183-97 |
| Sanchez-Ortiz, Efrain; Hahm, Byoung Kwon; Armstrong, David L et al. (2009) Protein phosphatase 5 protects neurons against amyloid-beta toxicity. J Neurochem 111:391-402 |
| Liao, Yanhong; Erxleben, Christian; Yildirim, Eda et al. (2007) Orai proteins interact with TRPC channels and confer responsiveness to store depletion. Proc Natl Acad Sci U S A 104:4682-7 |
| Erxleben, Christian; Liao, Yanhong; Gentile, Saverio et al. (2006) Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices. Proc Natl Acad Sci U S A 103:3932-7 |
| Gentile, Saverio; Darden, Thomas; Erxleben, Christian et al. (2006) Rac GTPase signaling through the PP5 protein phosphatase. Proc Natl Acad Sci U S A 103:5202-6 |
| Storey, Nina M; Gomez-Angelats, Mireia; Bortner, Carl D et al. (2003) Stimulation of Kv1.3 potassium channels by death receptors during apoptosis in Jurkat T lymphocytes. J Biol Chem 278:33319-26 |
| Erxleben, Christian; Gomez-Alegria, Claudio; Darden, Thomas et al. (2003) Modulation of cardiac Ca(V)1.2 channels by dihydropyridine and phosphatase inhibitor requires Ser-1142 in the domain III pore loop. Proc Natl Acad Sci U S A 100:2929-34 |
| Tian, Lijun; Coghill, Lorraine S; MacDonald, Stephen H-F et al. (2003) Leucine zipper domain targets cAMP-dependent protein kinase to mammalian BK channels. J Biol Chem 278:8669-77 |
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