Abstract

The role of the enzymes aldose reductase and aldehyde reductase in the onset and progression of complications associated with diabetes are being investigated. In the eye these complications include retinopathy, cataract, keratopathy, changes in pupil function, and iris and ciliary process structure changes. Under development are methods of pharmacological control of these enzymes to either delay or prevent the onset and progression of these complications. Events leading to the formation of several types of cataracts, as well as methods for controlling the onset of these cataracts through pharmacological intervention, are also being investigated.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Intramural Research (Z01)
Project #
1Z01EY000003-18
Application #
3877017
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
18
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Schlitzer, M; Rodriguez, L; Kador, P F (2001) Synthesis of potential aldose reductase inhibitors based on minimal pharmacophore requirements. J Pharm Pharmacol 53:831-9
Murata, M; Ohta, N; Sakurai, S et al. (2001) The role of aldose reductase in sugar cataract formation: aldose reductase plays a key role in lens epithelial cell death (apoptosis). Chem Biol Interact 130-132:617-25
Mizoguchi, T; Maeda, I; Yagi, K et al. (2001) Effect of bovine small intestine thioredoxin on aldose reductase activity. Chem Biol Interact 130-132:609-15
Lizak, M J; Datiles, M B; Aletras, A H et al. (2000) MRI of the human eye using magnetization transfer contrast enhancement. Invest Ophthalmol Vis Sci 41:3878-81
Sugiyama, K; Chen, Z; Lee, Y S et al. (2000) Isolation of a non-covalent aldose reductase-nucleotide-inhibitor complex. Biochem Pharmacol 59:329-36
Murata, M; Kador, P F; Sato, S (2000) Vascular endothelial growth factor (VEGF) enhances the expression of receptors and activates mitogen-activated protein (MAP) kinase of dog retinal capillary endothelial cells. J Ocul Pharmacol Ther 16:383-91
Kador, P F; Lee, J W; Fujisawa, S et al. (2000) Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats. J Ocul Pharmacol Ther 16:149-60
Sato, S; Sugiyama, K; Lee, Y S et al. (1999) Prevention of naphthalene-1,2-dihydrodiol-induced lens protein modifications by structurally diverse aldose reductase inhibitors. Exp Eye Res 68:601-8
Sugiyama, K; Wang, T C; Simpson, J T et al. (1999) Aldose reductase catalyzes the oxidation of naphthalene-1, 2-dihydrodiol for the formation of ortho-naphthoquinone. Drug Metab Dispos 27:60-7
Ohta, N; Tsai, J Y; Secchi, E F et al. (1999) Neutrophils in galactose-fed dogs: suppressed apoptosis and increased adhesion to retinal capillary endothelial cells. J Diabetes Complications 13:151-8

Showing the most recent 10 out of 18 publications