Pharmacology of Ocular Complications

Kador, P.

Abstract

Events leading to the onset of various ocular complications are being investigated. Specific studies include the role of enzymes aldose reductase and aldehyde reductase in the onset and progression of retinopathy, cataract, keratopathy, pupil function changes, and iris and ciliary process structure changes associated with diabetes and galactosemia. In addition, methods for either delaying or preventing the onset and progression of these complications through the pharmacological control of these enzymes are being developed. Also being studied are events leading to the formation of several types of cataracts, as well as methods for controlling the onset of these cataracts through pharmacological intervention.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Eye Institute (NEI)
• Type: Intramural Research (Z01)
• Project #: 1Z01EY000003-21
• Application #: 3777596
• Support Year: 21
• Fiscal Year: 1993

Institution

• Name: U.S. National Eye Institute
• Country: United States

Publications

Mizoguchi, T; Maeda, I; Yagi, K et al. (2001) Effect of bovine small intestine thioredoxin on aldose reductase activity. Chem Biol Interact 130-132:609-15

Schlitzer, M; Rodriguez, L; Kador, P F (2001) Synthesis of potential aldose reductase inhibitors based on minimal pharmacophore requirements. J Pharm Pharmacol 53:831-9

Murata, M; Ohta, N; Sakurai, S et al. (2001) The role of aldose reductase in sugar cataract formation: aldose reductase plays a key role in lens epithelial cell death (apoptosis). Chem Biol Interact 130-132:617-25

Sugiyama, K; Chen, Z; Lee, Y S et al. (2000) Isolation of a non-covalent aldose reductase-nucleotide-inhibitor complex. Biochem Pharmacol 59:329-36

Murata, M; Kador, P F; Sato, S (2000) Vascular endothelial growth factor (VEGF) enhances the expression of receptors and activates mitogen-activated protein (MAP) kinase of dog retinal capillary endothelial cells. J Ocul Pharmacol Ther 16:383-91

Kador, P F; Lee, J W; Fujisawa, S et al. (2000) Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats. J Ocul Pharmacol Ther 16:149-60

Lizak, M J; Datiles, M B; Aletras, A H et al. (2000) MRI of the human eye using magnetization transfer contrast enhancement. Invest Ophthalmol Vis Sci 41:3878-81

Sato, S; Sugiyama, K; Lee, Y S et al. (1999) Prevention of naphthalene-1,2-dihydrodiol-induced lens protein modifications by structurally diverse aldose reductase inhibitors. Exp Eye Res 68:601-8

Sugiyama, K; Wang, T C; Simpson, J T et al. (1999) Aldose reductase catalyzes the oxidation of naphthalene-1, 2-dihydrodiol for the formation of ortho-naphthoquinone. Drug Metab Dispos 27:60-7

Ohta, N; Tsai, J Y; Secchi, E F et al. (1999) Neutrophils in galactose-fed dogs: suppressed apoptosis and increased adhesion to retinal capillary endothelial cells. J Diabetes Complications 13:151-8