Abstract

In vivo functional long-term T-cell lines and T-cell clones are developed and maintained in vitro from both peripheral blood and ocular fluids of humans and animals. The phenotype and functional properties of these cells, as well as their interaction with ocular resident cells are being studied. The goal of these studies will be to identify the immunoreactive cells and mediators involved in the intraocular inflammatory process.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Intramural Research (Z01)
Project #
1Z01EY000184-06
Application #
3941650
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

St Leger, Anthony J; Hansen, Anna M; Karauzum, Hatice et al. (2018) STAT-3-independent production of IL-17 by mouse innate-like ?? T cells controls ocular infection. J Exp Med 215:1079-1090
Chen, Jun; Caspi, Rachel R; Chong, Wai Po (2018) IL-20 receptor cytokines in autoimmune diseases. J Leukoc Biol 104:953-959
Kielczewski, Jennifer L; Horai, Reiko; Jittayasothorn, Yingyos et al. (2016) Tertiary Lymphoid Tissue Forms in Retinas of Mice with Spontaneous Autoimmune Uveitis and Has Consequences on Visual Function. J Immunol 196:1013-25
Lee, Ellen J; Brown, Brieanna R; Vance, Emily E et al. (2016) Mincle Activation and the Syk/Card9 Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye. J Immunol 196:3148-58
Silver, Phyllis B; Silver, Phyllis; Horai, Reiko et al. (2015) Retina-specific T regulatory cells bring about resolution and maintain remission of autoimmune uveitis. J Immunol 194:3011-9
Chong, Wai Po; Horai, Reiko; Mattapallil, Mary J et al. (2014) IL-27p28 inhibits central nervous system autoimmunity by concurrently antagonizing Th1 and Th17 responses. J Autoimmun 50:12-22
London, Anat; Benhar, Inbal; Mattapallil, Mary J et al. (2013) Functional macrophage heterogeneity in a mouse model of autoimmune central nervous system pathology. J Immunol 190:3570-8
Horai, Reiko; Silver, Phyllis B; Chen, Jun et al. (2013) Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen. J Autoimmun 44:21-33
Kyger, Madison; Worley, Aneta; Huan, Jianya et al. (2013) Effective Arrestin-Specific Immunotherapy of Experimental Autoimmune Uveitis with RTL: A Prospect for Treatment of Human Uveitis. Transl Vis Sci Technol 2:1
Hansen, Anna M; Caspi, Rachel R (2009) Targeting lymphotoxin depletes pathogenic T cells. Nat Med 15:732-3

Showing the most recent 10 out of 59 publications