Abstract

Identity and topographic localization of immunocompetent cells in rats with experimental autoimmune uveoretinitis were analyzed by immunohistochemical studies. The lymphocyte population at the inflammatory sites was found to change markedly during the course of disease. In the early stage, T-helper/inducers are the pedominant cells in the eye. A relative increase of T-suppressor/cytotoxic cells in the late stage were observed. These kinetics can be influenced by cyclosporine and dexamethosone treatment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Intramural Research (Z01)
Project #
1Z01EY000222-01
Application #
3965393
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Panda, Puneet; Forooghian, Farzin; Goodglick, Todd et al. (2010) Orbital lymphoma masquerading as panuveitis. Ocul Immunol Inflamm 18:181-3
Tuo, Jingsheng; Ross, Robert J; Herzlich, Alexandra A et al. (2009) A high omega-3 fatty acid diet reduces retinal lesions in a murine model of macular degeneration. Am J Pathol 175:799-807
Lu, Ailing; Ng, Lily; Ma, Michelle et al. (2009) Retarded developmental expression and patterning of retinal cone opsins in hypothyroid mice. Endocrinology 150:1536-44
MacDonald, Ian M; Russell, Laurie; Chan, Chi-Chao (2009) Choroideremia: new findings from ocular pathology and review of recent literature. Surv Ophthalmol 54:401-7
Cimino, Luca; Chan, Chi-Chao; Shen, DeFen et al. (2009) Ocular involvement in nasal natural killer T-cell lymphoma. Int Ophthalmol 29:275-9
Fujimoto, C; Klinman, D M; Shi, G et al. (2009) A suppressive oligodeoxynucleotide inhibits ocular inflammation. Clin Exp Immunol 156:528-34
Wong, Wai T; Yeh, Steven; Chan, Chi-Chao et al. (2008) Retinal vascular proliferation as an ocular manifestation of von Hippel-Lindau disease. Arch Ophthalmol 126:637-43
Sen, H Nida; Chan, Chi-Chao; Byrnes, Gordon et al. (2008) Intravitreal methotrexate resistance in a patient with primary intraocular lymphoma. Ocul Immunol Inflamm 16:29-33
Detrick, Barbara; Lee, Maria Teresa; Chin, Marian S et al. (2008) Experimental coronavirus retinopathy (ECOR): retinal degeneration susceptible mice have an augmented interferon and chemokine (CXCL9, CXCL10) response early after virus infection. J Neuroimmunol 193:28-37
Wang, Jie Jin; Ross, Robert J; Tuo, Jingsheng et al. (2008) The LOC387715 polymorphism, inflammatory markers, smoking, and age-related macular degeneration. A population-based case-control study. Ophthalmology 115:693-9

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