Abstract

Although weight gain and obesity are nearly universal features of Cushings syndrome, we hypothesized that screening results would have poor specificity in an obese population. The study is based in a weight loss clinic and enrolls individuals with at least two additional signs or symptoms of Cushings syndrome. Preliminary analysis suggests a high rate (nearly 20%) of falsely positive screening tests in patients who are found to be normal on subsequent confirmatory testing. If confirmed after further study, these results suggest that current recommendations for screening may need revision.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Intramural Research (Z01)
Project #
1Z01HD000638-15
Application #
7734700
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
15
Fiscal Year
2008
Total Cost
$61,489
Indirect Cost

  Institution

Name
Eunice Kennedy Shriver National Institute of Child Health & Human Development
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Raff, Hershel; Sharma, Susmeeta T; Nieman, Lynnette K (2014) Physiological basis for the etiology, diagnosis, and treatment of adrenal disorders: Cushing's syndrome, adrenal insufficiency, and congenital adrenal hyperplasia. Compr Physiol 4:739-69
Sharma, S T; Nieman, L K (2013) Is prolactin measurement of value during inferior petrosal sinus sampling in patients with adrenocorticotropic hormone-dependent Cushing's Syndrome? J Endocrinol Invest 36:1112-6
Sharma, S T; Nieman, L K (2012) Prolonged remission after long-term treatment with steroidogenesis inhibitors in Cushing's syndrome caused by ectopic ACTH secretion. Eur J Endocrinol 166:531-6
Baid, Smita K; Rubino, Domenica; Sinaii, Ninet et al. (2009) Specificity of screening tests for Cushing's syndrome in an overweight and obese population. J Clin Endocrinol Metab 94:3857-64
Nieman, Lynnette K; Biller, Beverly M K; Findling, James W et al. (2008) The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 93:1526-40
Nieman, Lynnette (2007) Editorial: The dexamethasone-suppressed corticotropin-releasing hormone test for the diagnosis of Cushing's syndrome: what have we learned in 14 years? J Clin Endocrinol Metab 92:2876-8
Baid, Smita K; Sinaii, Ninet; Wade, Matt et al. (2007) Radioimmunoassay and tandem mass spectrometry measurement of bedtime salivary cortisol levels: a comparison of assays to establish hypercortisolism. J Clin Endocrinol Metab 92:3102-7
Nieman, Lynnette K (2007) Screening for reversible osteoporosis: is cortisol a culprit? Ann Intern Med 147:582-4
Newell-Price, John; Bertagna, Xavier; Grossman, Ashley B et al. (2006) Cushing's syndrome. Lancet 367:1605-17
Weil, Robert J; Vortmeyer, Alexander O; Nieman, Lynnette K et al. (2006) Surgical remission of pituitary adenomas confined to the neurohypophysis in Cushing's disease. J Clin Endocrinol Metab 91:2656-64

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