Abstract

Previous studies from our laboratory have implicated a population of activated suppressor lymphocytes which produce an inhibitory lymphokine as pathogenic in patients with bone marrow failure. These cells are detectable in abnormally high numbers in the circulation of patients with aplastic anemia. Production of gamma interferon by activated suppressor cells probably explains other laboratories' previous results showing inhibition in co-culture by patients' cells of normal hematopoiesis. Current studies have been directed at the changes in lymphocyte phenotypes and lymphokine production in patients that follow treatment with antithymocyte globulin (ATG); the mechanism of action of ATG in aplastic anemia; and the interaction in vitro of gamma interferon with other soluble mediators of immune function. The scope of studies of aplastic anemia has been broadened by collaborations with investigators in the Far East, where aplastic anemia is a more common disorder than in the United States or Western Europe.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Intramural Research (Z01)
Project #
1Z01HL002315-04
Application #
3966619
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
U.S. National Heart Lung and Blood Inst
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Kojima, Seiji; Nakao, Shinji; Young, Neal et al. (2011) The Third Consensus Conference on the treatment of aplastic anemia. Int J Hematol 93:832-7
Sloand, Elaine; Pfannes, Loretta; Ling, Casey et al. (2010) Graft-vs.-Host Disease: Role of Inflammation in the development of chromosomal abnormalities of keratinocytes. Biol Blood Marrow Transplant :
Calado, Rodrigo T; Regal, Joshua A; Hills, Mark et al. (2009) Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. Proc Natl Acad Sci U S A 106:1187-92
Scheinberg, Phillip; Wu, Colin O; Nunez, Olga et al. (2009) Treatment of severe aplastic anemia with a combination of horse antithymocyte globulin and cyclosporine, with or without sirolimus: a prospective randomized study. Haematologica 94:348-54
Valdez, Jessica M; Scheinberg, Phillip; Young, Neal S et al. (2009) Infections in patients with aplastic anemia. Semin Hematol 46:269-76
Calado, Rodrigo T; Yewdell, William T; Wilkerson, Keisha L et al. (2009) Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells. Blood 114:2236-43
Young, Neal S (2009) Paroxysmal nocturnal hemoglobinuria and myelodysplastic syndromes: clonal expansion of PIG-A-mutant hematopoietic cells in bone marrow failure. Haematologica 94:3-7
Visconte, Valeria; Raghavachari, Nalini; Liu, Delong et al. (2009) Phenotypic and functional characterization of a mouse model of targeted Pig-a deletion in hematopoietic cells. Haematologica :
Tang, Yong; Chen, Jichun; Young, Neal S (2009) Expansion of haematopoietic stem cells from normal donors and bone marrow failure patients by recombinant hoxb4. Br J Haematol 144:603-12
Sloand, Elaine M; Wu, Colin O; Greenberg, Peter et al. (2008) Factors affecting response and survival in patients with myelodysplasia treated with immunosuppressive therapy. J Clin Oncol 26:2505-11

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