Circadian rhythms and environmental lighting regulate a number of endocrine and behavioral functions. Dispersed chick pineal cells remain rhythmic and responsive to in culture. Norepinephrine mimics the acute inhibitory effect, but not the phase shifting effect, of light and can prevent damping of the melatonin rhythm Norepinephrine and light regulate coupling of the pacemaker to melatonin synthesis. The G-proteins, Gs-alpha and its beta- gamma subunits are found in the cytoplasm as well as in the membranes and may translocate in response to stimulation. Adenylyl cyclase activity appears to be rhythmic. Vasoactive intestinal peptide stimulates melatonin synthesis but does not show alpha- l-adrenergic potentiation. Changes in cell volume induced by hypertonic solutions mimic the effects of light on the underlying pacemaker.
| Yadav, Geetha; Straume, Martin; Heath 3rd, James et al. (2003) Are changes in MAPK/ERK necessary or sufficient for entrainment in chick pineal cells? J Neurosci 23:10021-31 |
| Zatz, Martin (2003) Stands to reason. J Biol Rhythms 18:3 |
| Zatz, Martin (2002) Who do you think you are? J Biol Rhythms 17:283 |
| Zatz, Martin (2002) Ya gotta believe! J Biol Rhythms 17:3 |
| Natesan, Arjun; Geetha, L; Zatz, Martin (2002) Rhythm and soul in the avian pineal. Cell Tissue Res 309:35-45 |
| Zatz, Martin (2002) Can't get no ... satisfaction! J Biol Rhythms 17:391 |
| Zatz, M; Gastel, J A; Heath 3rd, J R et al. (2000) Chick pineal melatonin synthesis: light and cyclic AMP control abundance of serotonin N-acetyltransferase protein. J Neurochem 74:2315-21 |
| Bernard, M; Guerlotte, J; Greve, P et al. (1999) Melatonin synthesis pathway: circadian regulation of the genes encoding the key enzymes in the chicken pineal gland and retina. Reprod Nutr Dev 39:325-34 |
