Abstract

The major areas of effort in this project have been (1) to develop new tracers or other approaches for the study of neurotransmitter function in normal and abnormal physiology; and (2) to apply available tracer methodologies to the study of neuropsychiatric disorders. To these ends the following achievements are notable. PET scans of regional glucose metabolism have revealed that (1)Panic disorder patients have lower left to right hippocampus ratios than normals. This appears to be primarily the result of increased activity in the right hippocampus. (2)Hyperactive adults with childhood onset have reduced global cerebral glucose metabolism. This alteration is most prominent in the areas of the brain related to motor function. (3)Treatment of obsessive-compulsive patients with clomipramine (CMI), the most effective pharmacologic intervention in the disorder, is associated with a reduction in the higher than normal orbitofrontal metabolism observed in patients who are not receiving medications.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH000507-08
Application #
3880848
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Cohen, Robert M; Szczepanik, Joanna; McManus, Michael et al. (2006) Hippocampal atrophy in the healthy is initially linear and independent of age. Neurobiol Aging 27:1385-94
Cannon-Spoor, H Eleanor; Levy, James A; Zubenko, George S et al. (2005) Effects of previous major depressive illness on cognition in Alzheimer disease patients. Am J Geriatr Psychiatry 13:312-8
Toyama, Hiroshi; Ye, Daniel; Ichise, Masanori et al. (2005) PET imaging of brain with the beta-amyloid probe, [11C]6-OH-BTA-1, in a transgenic mouse model of Alzheimer's disease. Eur J Nucl Med Mol Imaging 32:593-600
Levy, James A; Bergeson, Judy; Putnam, Karen et al. (2004) Context-specific memory and apolipoprotein E (ApoE) epsilon 4: cognitive evidence from the NIMH prospective study of risk for Alzheimer's disease. J Int Neuropsychol Soc 10:362-70
Sunderland, Trey; Mirza, Nadeem; Putnam, Karen T et al. (2004) Cerebrospinal fluid beta-amyloid1-42 and tau in control subjects at risk for Alzheimer's disease: the effect of APOE epsilon4 allele. Biol Psychiatry 56:670-6
Podruchny, Teresa A; Connolly, Catherine; Bokde, Arun et al. (2003) In vivo muscarinic 2 receptor imaging in cognitively normal young and older volunteers. Synapse 48:39-44
Cohen, Robert M; Podruchny, Teresa A; Bokde, Arun L W et al. (2003) Higher in vivo muscarinic-2 receptor distribution volumes in aging subjects with an apolipoprotein E-epsilon4 allele. Synapse 49:150-6
Doudet, D J; Holden, J E; Jivan, S et al. (2000) In vivo PET studies of the dopamine D2 receptors in rhesus monkeys with long-term MPTP-induced parkinsonism. Synapse 38:105-13
Elkashef, A M; Doudet, D; Bryant, T et al. (2000) 6-(18)F-DOPA PET study in patients with schizophrenia. Positron emission tomography. Psychiatry Res 100:11-Jan
Wyatt, R J; Henter, I D; Bartko, J J (1999) The long-term effects of placebo in patients with chronic schizophrenia. Biol Psychiatry 46:1092-105

Showing the most recent 10 out of 11 publications