Abstract

This project focuses on the behavioral neurophysiology of the frontal lobe of primates. Through the development of a number of novel behavioral methods, we have begun to distinguish neuronal signals reflecting sensory and perceptual processes from those involving the selection and control of motor behavior. We have found that the former predominate in prefrontal cortex, whereas the later can be most often identified in the premotor cortex. We have focused on two kinds of rules in a study of motor learning: conditional motor rules and skills. During the past year we have begun projects that aim to identify neural signals reflecting behavior-guiding rules in the prefrontal cortex and to distinguish the mechanisms of visual perception from those of visually guided action. We have also been engaged in the writing of several scholarly reviews on the subject of this project and its relation to cognate fields.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH001092-18
Application #
2578693
Study Section
Special Emphasis Panel (LNP)
Project Start
Project End
Budget Start
Budget End
Support Year
18
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Nougaret, Simon; Genovesio, Aldo (2018) Learning the meaning of new stimuli increases the cross-correlated activity of prefrontal neurons. Sci Rep 8:11680
Marcos, Encarni; Nougaret, Simon; Tsujimoto, Satoshi et al. (2018) Outcome Modulation Across Tasks in the Primate Dorsolateral Prefrontal Cortex. Neuroscience 371:96-105
Marcos, Encarni; Tsujimoto, Satoshi; Genovesio, Aldo (2016) Event- and time-dependent decline of outcome information in the primate prefrontal cortex. Sci Rep 6:25622
Marcos, Encarni; Genovesio, Aldo (2016) Determining Monkey Free Choice Long before the Choice Is Made: The Principal Role of Prefrontal Neurons Involved in Both Decision and Motor Processes. Front Neural Circuits 10:75
Genovesio, Aldo; Cirillo, Rossella; Tsujimoto, Satoshi et al. (2015) Automatic comparison of stimulus durations in the primate prefrontal cortex: the neural basis of across-task interference. J Neurophysiol 114:48-56
Genovesio, Aldo; Tsujimoto, Satoshi; Navarra, Giulia et al. (2014) Autonomous encoding of irrelevant goals and outcomes by prefrontal cortex neurons. J Neurosci 34:1970-8
Tsujimoto, Satoshi; Genovesio, Aldo; Wise, Steven P (2012) Neuronal activity during a cued strategy task: comparison of dorsolateral, orbital, and polar prefrontal cortex. J Neurosci 32:11017-31
Genovesio, Aldo; Tsujimoto, Satoshi; Wise, Steven P (2012) Encoding goals but not abstract magnitude in the primate prefrontal cortex. Neuron 74:656-62
Genovesio, Aldo; Tsujimoto, Satoshi; Wise, Steven P (2011) Prefrontal cortex activity during the discrimination of relative distance. J Neurosci 31:3968-80
Tsujimoto, Satoshi; Genovesio, Aldo; Wise, Steven P (2011) Comparison of strategy signals in the dorsolateral and orbital prefrontal cortex. J Neurosci 31:4583-92

Showing the most recent 10 out of 39 publications