Neuropeptide Secretion, Synthesis and Action in Neural, Endocrine and Immune Cell

Eiden, L E.

Abstract

We are examining the molecular mechanisms of neuropeptide secretion, neuropeptide expression and biosynthesis and neuropeptide interactions with their receptors in the developing and mature neuroendocrine system. We are attempting to understand the structural features of peptides and proteins that confer molecular specificity on these three processes. We hope to characterize and develop pharmacological agents that mimick this specificity.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Mental Health (NIMH)
• Type: Intramural Research (Z01)
• Project #: 1Z01MH002386-02
• Application #: 3944815
• Support Year: 2
• Fiscal Year: 1987

Institution

• Name: U.S. National Institute of Mental Health
• Country: United States

Publications

Emery, Andrew C; Xu, Wenqin; Eiden, Maribeth V et al. (2017) Guanine nucleotide exchange factor Epac2-dependent activation of the GTP-binding protein Rap2A mediates cAMP-dependent growth arrest in neuroendocrine cells. J Biol Chem 292:12220-12231

Emery, Andrew C; Alvarez, Ryan A; Eiden, Maribeth V et al. (2017) Differential Pharmacophore Definition of the cAMP Binding Sites of Neuritogenic cAMP Sensor-Rapgef2, Protein Kinase A, and Exchange Protein Activated by cAMP in Neuroendocrine Cells Using an Adenine-Based Scaffold. ACS Chem Neurosci 8:1500-1509

Jenkins, Danielle E; Sreenivasan, Dharshini; Carman, Fiona et al. (2016) Interleukin-6-mediated signaling in adrenal medullary chromaffin cells. J Neurochem 139:1138-1150

Jiang, Sunny Zhihong; Eiden, Lee E (2016) Activation of the HPA axis and depression of feeding behavior induced by restraint stress are separately regulated by PACAPergic neurotransmission in the mouse. Stress 19:374-82

Emery, Andrew C; Alvarez, Ryan A; Abboud, Philip et al. (2016) C-terminal amidation of PACAP-38 and PACAP-27 is dispensable for biological activity at the PAC1 receptor. Peptides 79:39-48

Schütz, Burkhard; Schäfer, Martin K-H; Gördes, Markus et al. (2015) Satb2-independent acquisition of the cholinergic sudomotor phenotype in rodents. Cell Mol Neurobiol 35:205-16

Mustafa, Tomris (2013) Pituitary adenylate cyclase-activating polypeptide (PACAP): a master regulator in central and peripheral stress responses. Adv Pharmacol 68:445-57

Samal, Babru; Ait-Ali, Djida; Bunn, Stephen et al. (2013) Discrete signal transduction pathway utilization by a neuropeptide (PACAP) and a cytokine (TNF-alpha) first messenger in chromaffin cells, inferred from coupled transcriptome-promoter analysis of regulated gene cohorts. Peptides 45:48-60

Schäfer, M K-H; Hartwig, N R; Kalmbach, N et al. (2013) Species-specific vesicular monoamine transporter 2 (VMAT2) expression in mammalian pancreatic beta cells: implications for optimising radioligand-based human beta cell mass (BCM) imaging in animal models. Diabetologia 56:1047-56

Smith, Corey B; Eiden, Lee E (2012) Is PACAP the major neurotransmitter for stress transduction at the adrenomedullary synapse? J Mol Neurosci 48:403-12