We are studying 1) tissue-specific neuropeptide expression and 2) regulation of neuropeptide biosynthesis and secretion in developing and mature neuroendocrine cells. We would like to understand how second messenger systems activated by neurotransmitters and electrical activity converge on the regulatory elements of neuropeptide genes to effect the establishment of neuropeptide phenotypes during development, and affect the rates of neuropeptide secretion and gene transcription in normal and pathophysiolgocial states.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002386-05
Application #
3859916
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1991
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Emery, Andrew C; Xu, Wenqin; Eiden, Maribeth V et al. (2017) Guanine nucleotide exchange factor Epac2-dependent activation of the GTP-binding protein Rap2A mediates cAMP-dependent growth arrest in neuroendocrine cells. J Biol Chem 292:12220-12231
Emery, Andrew C; Alvarez, Ryan A; Eiden, Maribeth V et al. (2017) Differential Pharmacophore Definition of the cAMP Binding Sites of Neuritogenic cAMP Sensor-Rapgef2, Protein Kinase A, and Exchange Protein Activated by cAMP in Neuroendocrine Cells Using an Adenine-Based Scaffold. ACS Chem Neurosci 8:1500-1509
Jenkins, Danielle E; Sreenivasan, Dharshini; Carman, Fiona et al. (2016) Interleukin-6-mediated signaling in adrenal medullary chromaffin cells. J Neurochem 139:1138-1150
Jiang, Sunny Zhihong; Eiden, Lee E (2016) Activation of the HPA axis and depression of feeding behavior induced by restraint stress are separately regulated by PACAPergic neurotransmission in the mouse. Stress 19:374-82
Emery, Andrew C; Alvarez, Ryan A; Abboud, Philip et al. (2016) C-terminal amidation of PACAP-38 and PACAP-27 is dispensable for biological activity at the PAC1 receptor. Peptides 79:39-48
Schütz, Burkhard; Schäfer, Martin K-H; Gördes, Markus et al. (2015) Satb2-independent acquisition of the cholinergic sudomotor phenotype in rodents. Cell Mol Neurobiol 35:205-16
Mustafa, Tomris (2013) Pituitary adenylate cyclase-activating polypeptide (PACAP): a master regulator in central and peripheral stress responses. Adv Pharmacol 68:445-57
Samal, Babru; Ait-Ali, Djida; Bunn, Stephen et al. (2013) Discrete signal transduction pathway utilization by a neuropeptide (PACAP) and a cytokine (TNF-alpha) first messenger in chromaffin cells, inferred from coupled transcriptome-promoter analysis of regulated gene cohorts. Peptides 45:48-60
Schäfer, M K-H; Hartwig, N R; Kalmbach, N et al. (2013) Species-specific vesicular monoamine transporter 2 (VMAT2) expression in mammalian pancreatic beta cells: implications for optimising radioligand-based human beta cell mass (BCM) imaging in animal models. Diabetologia 56:1047-56
Smith, Corey B; Eiden, Lee E (2012) Is PACAP the major neurotransmitter for stress transduction at the adrenomedullary synapse? J Mol Neurosci 48:403-12

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