Abstract

Postmortem Studies in neuropsychiatric disorders test hypotheses with regard to schizophrenia, suicide, and addictions. New findings in schizophrenia include the following: (1) increased met- enkephalin in the substantia nigra of schizophrenic patients versus controls; (2) normal dopamine reuptake sites in putamen of schizophrenic patients versus controls; (3) an association of age disorientation (an aspect of dementia) with ventriculomegaly in schizophrenic patients; and (4) no evidence for hippocampal disarray in schizophrenic patients. New findings in suicide studies included normal amino acid concentrations in a number of brain regions. In addition, a study of heat shock proteins found tha heterozygosity was present in 30% of brains of subject who died from causes other than suicide. However, in 21 suicides (100%), the heat shock proteins were homozygous. Lastly, hippocampal glutamate binding was increased in alcoholic brains as compared with controls. This increase was especially pronounced in alcoholics who died from seizures secondary to alcohol withdrawal.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002399-03
Application #
3922027
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Kaalund, S S; Newburn, E N; Ye, T et al. (2014) Contrasting changes in DRD1 and DRD2 splice variant expression in schizophrenia and affective disorders, and associations with SNPs in postmortem brain. Mol Psychiatry 19:1258-66
Hyde, Thomas M; Lipska, Barbara K; Ali, Towhid et al. (2011) Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia. J Neurosci 31:11088-95
Bigos, Kristin L; Mattay, Venkata S; Callicott, Joseph H et al. (2010) Genetic variation in CACNA1C affects brain circuitries related to mental illness. Arch Gen Psychiatry 67:939-45
Montague, D; Weickert, C S; Tomaskovic-Crook, E et al. (2008) Oestrogen receptor alpha localisation in the prefrontal cortex of three mammalian species. J Neuroendocrinol 20:893-903
Weickert, Cynthia Shannon; Rothmond, Debora A; Hyde, Thomas M et al. (2008) Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients. Schizophr Res 98:105-10
Weickert, C S; Webster, M J; Gondipalli, P et al. (2007) Postnatal alterations in dopaminergic markers in the human prefrontal cortex. Neuroscience 144:1109-19
Meyer-Lindenberg, Andreas; Straub, Richard E; Lipska, Barbara K et al. (2007) Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition. J Clin Invest 117:672-82
Straub, R E; Lipska, B K; Egan, M F et al. (2007) Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression. Mol Psychiatry 12:854-69
Mathew, Shiny V; Law, Amanda J; Lipska, Barbara K et al. (2007) Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1. Hum Mol Genet 16:2921-32
Tseng, Kuei-Yuan; Lewis, Barbara L; Lipska, Barbara K et al. (2007) Post-pubertal disruption of medial prefrontal cortical dopamine-glutamate interactions in a developmental animal model of schizophrenia. Biol Psychiatry 62:730-8

Showing the most recent 10 out of 73 publications