The goals of this project are to detect and accurately describe peri- menopausal mood disorders, explore their pathophysiology and response to pharmacological and environmental manipulation, and to document the relationship between reproductive endocrine change and disorders of mood as a way of further investigating the neurobiology of psychiatric illness. Findings to date include the following: 1) significant improvement of multiple symptoms of perimenopausal depression following estrogen replacement in 28 women with perimenopausal depression; 2) decreased libido, sexual arousal, and erectile function in 11 men participating in the Lupron trial prior to testosterone addback; 3) decreased vigor and exercise-associated pleasure in men during the hypogonadal state.
| Harsh, Veronica; Schmidt, Peter J; Rubinow, David R (2007) The menopause transition: the next neuroendocrine frontier. Expert Rev Neurother 7:S7-10 |
| Schmidt, Peter J; Cardoso, Graca M P; Ross, Judith L et al. (2006) Shyness, social anxiety, and impaired self-esteem in Turner syndrome and premature ovarian failure. JAMA 295:1374-6 |
| Morrison, John H; Brinton, Roberta D; Schmidt, Peter J et al. (2006) Estrogen, menopause, and the aging brain: how basic neuroscience can inform hormone therapy in women. J Neurosci 26:10332-48 |
| Richards, Misty; Rubinow, David R; Daly, Robert C et al. (2006) Premenstrual symptoms and perimenopausal depression. Am J Psychiatry 163:133-7 |
| Schmidt, Peter J; Rubinow, David R (2006) Reproductive ageing, sex steroids and depression. J Br Menopause Soc 12:178-85 |
| Schmidt, Peter J (2005) Mood, depression, and reproductive hormones in the menopausal transition. Am J Med 118 Suppl 12B:54-8 |
| Schmidt, Peter J (2005) Depression, the perimenopause, and estrogen therapy. Ann N Y Acad Sci 1052:27-40 |
| Rubinow, David R; Roca, Catherine A; Schmidt, Peter J et al. (2005) Testosterone suppression of CRH-stimulated cortisol in men. Neuropsychopharmacology 30:1906-12 |
| Bloch, Miki; Rubinow, David R; Schmidt, Peter J et al. (2005) Cortisol response to ovine corticotropin-releasing hormone in a model of pregnancy and parturition in euthymic women with and without a history of postpartum depression. J Clin Endocrinol Metab 90:695-9 |
| Schmidt, Peter J; Daly, Robert C; Bloch, Miki et al. (2005) Dehydroepiandrosterone monotherapy in midlife-onset major and minor depression. Arch Gen Psychiatry 62:154-62 |
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