Abstract

The pharmacology of the D-1 receptor was investigated with biochemical techniques. The binding of (125I) SCH 23982 to specific binding sites in the caudate putamen and s. nigra of the rat brain was characterized. The nonspecific binding of this ligand to melanin was also investigated. This latter signal formed the basis for the noninvasive imaging of pigmented melanomas. The role of cAMP and calcium in the process of pituitary hormone release was investigated. cAMP elevation in the 7315c tumor cell potentiates the capacity of the cell to respond to a fixed increment in the concentration of cytosolic calcium without changing the molar potency of calcium as a stimulatory agent. The substrates for cAMP-dependent protein kinase endogenous to the pituitary gland were characterized in FY 86. A number of phosphate receptors were identified.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Intramural Research (Z01)
Project #
1Z01NS002263-10
Application #
3968946
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
National Institute of Neurological Disorders and Stroke
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Skinbjerg, Mette; Liow, Jeih-San; Seneca, Nicholas et al. (2010) D2 dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: a PET study in a receptor internalization-deficient mouse model. Neuroimage 50:1402-7
Wang, Zheng; Armando, Ines; Asico, Laureano D et al. (2007) The elevated blood pressure of human GRK4gamma A142V transgenic mice is not associated with increased ROS production. Am J Physiol Heart Circ Physiol 292:H2083-92
Hernandez-Echeagaray, Elizabeth; Cepeda, Carlos; Ariano, Marjorie A et al. (2007) Dopamine reduction of GABA currents in striatal medium-sized spiny neurons is mediated principally by the D(1) receptor subtype. Neurochem Res 32:229-40
Yang, Zhiwei; Asico, Laureano D; Yu, Peiying et al. (2006) D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure. Am J Physiol Regul Integr Comp Physiol 290:R96-R104
Tomiyama, Katsunori; Makihara, Yasuyuki; Yamamoto, Hiroshi et al. (2006) Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 receptor or DARPP-32 transduction 'knockout'. Eur Neuropsychopharmacol 16:437-45
Rankin, Michele L; Marinec, Paul S; Cabrera, David M et al. (2006) The D1 dopamine receptor is constitutively phosphorylated by G protein-coupled receptor kinase 4. Mol Pharmacol 69:759-69
Zeng, Chunyu; Yang, Zhiwei; Wang, Zheng et al. (2005) Interaction of angiotensin II type 1 and D5 dopamine receptors in renal proximal tubule cells. Hypertension 45:804-10
Yang, Zhiwei; Asico, Laureano D; Yu, Peiying et al. (2005) D5 dopamine receptor regulation of phospholipase D. Am J Physiol Heart Circ Physiol 288:H55-61
O'Sullivan, Gerard J; Kinsella, Anthony; Sibley, David R et al. (2005) Ethological resolution of behavioural topography and D1-like versus D2-like agonist responses in congenic D5 dopamine receptor mutants: identification of D5:D2-like interactions. Synapse 55:201-11
Kudwa, A E; Dominguez-Salazar, E; Cabrera, D M et al. (2005) Dopamine D5 receptor modulates male and female sexual behavior in mice. Psychopharmacology (Berl) 180:206-14

Showing the most recent 10 out of 32 publications