This project encompasses a wide scope of statistical collaboration and consultation with laboratories and branches within the Division of Intramural Research (DIR), and with other neuroscience units outside NIH. Particular consideration is given to statistical planning and design of experiments, statistical analysis of data, and statistical inference. Examples of current studies include: clinical trial of bioequivalence of alpha- mannose-terminated glucocerebrosidase from natural and recombinant sources, clinical course and long-term outcome of patients treated with CeredaseTM Gaucher' evaluation of skeletal responses of Gaucher patients treated with CeredaseTM (DMNB); identification of factors associated with post-operative status of neurosurgical patients after trans-sphenoidal pituitary surgery (SNB); PET measurement of the effect of time from last seizure and seizure type on metabolic change, prevalence study of neurologic diseases in the Navajo tribe (ERB); modeling lesion recurrence in relapsing-remitting MS, clinical trial of DSG on lesion development in relapsing-remitting MS, monitoring MRI T2 weighted imaging in relapsing-remitting MS; examining the effect of accumulation of disease white matter in patients with relapsing-remitting MS (NIB); study of abnormal facilitation response to transcranial magnetic stimulation in PD patients, identification of deficits associated with """"""""over use"""""""" syndrome in pianists, two clinical trials of IV/IG in neuromuscular disorders, follow-up study of twins discordant for paralytic polio and subsequent post-polio syndrome; clinical trial of amantadine for the treatment of post-polio fatigue clinical trail of buspirone for the treatment of cerebellar ataxia; classification of MSA, PAF, and healthy individuals based on electrophysiological tests of autonomic function (MNB); validation study of consultations provided by U.S. drug information centers (CC); incidence study of nervous system tumors in Israel; incidence study of motor neuron disease on Guam, population-based case-control study of electronic fetal monitoring abnormalities as risk factors for CP in children weighing more than 2500g; comparison of risk factors for CP in low birthweight versus term birthweight children; planning and design of a clinical trial of magnesium sulfate for the reduction of CP in premature births (NEB); development of Markov models for rapidly cycling bipolar disorder(NIMH); studies of silent stroke risk factors for a subsequent stroke; recursive partitioning and logistic modeling for determination of risk of a cardiac source of embolism for ischemic stroke stroke.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Intramural Research (Z01)
Project #
1Z01NS002652-12
Application #
2579553
Study Section
Special Emphasis Panel (BFSB)
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
City
State
Country
United States
Zip Code
Nelson, Karin B; Grether, Judith K; Dambrosia, James M et al. (2003) Neonatal cytokines and cerebral palsy in very preterm infants. Pediatr Res 53:600-7
Schiffmann, Raphael; Mankin, Henry; Dambrosia, James M et al. (2002) Decreased bone density in splenectomized Gaucher patients receiving enzyme replacement therapy. Blood Cells Mol Dis 28:288-96
Zeuner, Kirsten E; Bara-Jimenez, William; Noguchi, Patricia S et al. (2002) Sensory training for patients with focal hand dystonia. Ann Neurol 51:593-8
Mittendorf, Robert; Dambrosia, James; Pryde, Peter G et al. (2002) Association between the use of antenatal magnesium sulfate in preterm labor and adverse health outcomes in infants. Am J Obstet Gynecol 186:1111-8
Mittendorf, Robert; Dambrosia, James; Dammann, Olaf et al. (2002) Association between maternal serum ionized magnesium levels at delivery and neonatal intraventricular hemorrhage. J Pediatr 140:540-6
Nelson, K B; Grether, J K; Croen, L A et al. (2001) Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardation. Ann Neurol 49:597-606
Altarescu, G M; Goldfarb, L G; Park, K Y et al. (2001) Identification of fifteen novel mutations and genotype-phenotype relationship in Fabry disease. Clin Genet 60:46-51
Altarescu, G; Hill, S; Wiggs, E et al. (2001) The efficacy of enzyme replacement therapy in patients with chronic neuronopathic Gaucher's disease. J Pediatr 138:539-47
Baird, A E; Dambrosia, J; Janket, S et al. (2001) A three-item scale for the early prediction of stroke recovery. Lancet 357:2095-9
Spanaki, M V; Kopylev, L; DeCarli, C et al. (2000) Postoperative changes in cerebral metabolism in temporal lobe epilepsy. Arch Neurol 57:1447-52

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