In FY 2001, in collaboration with Drs. Grether, Dambrosia, Phillips & Dickens, we reported that 4 of 8 neuropeptides or neurotrophins measured in archived neonatal blood distinguished children with autism or mental retardation from controls. With Dr. P. Nelson (NICHD), new clinical samples of children with autism, Down syndrome, other mental retardation, and controls are now being tested by techniques other than those previously employed, in order to re-evaluate and extend the initial observations. Dr. K. Nelson will be a consultant and collaborator in the CA Department of Health Services recently-awarded CDC Autism Center of Excellence grant, which will provide a source for biological samples of well-described clinical cases for studies of biological markers and inflammatory indicators. Our recent studies of cerebral palsy include investigation of coagulation disorders, a cause of pediatric and perinatal stroke now been recognized as an etiologic factor in CP. Three publications relating to pediatric stroke are in press. Results of a PCR study of neonatal blood for factors relating to clotting mechanisms in premature children with cerebral palsy and controls, a collaboration with Drs. Grether, ?Lammer, Iovannisci, and Dambrosia, are under analysis
| Hankins, Gary D V; MacLennan, Alastair H; Speer, Michael E et al. (2006) Obstetric litigation is asphyxiating our maternity services. Obstet Gynecol 107:1382-5 |
| Nelson, Karin B; Leviton, Alan (2006) Hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 354:1643-5; author reply 1643-5 |
| Lynch, John Kylan; Han, Christina J; Nee, Linda E et al. (2005) Prothrombotic factors in children with stroke or porencephaly. Pediatrics 116:447-53 |
| Wu, Yvonne W; Lynch, John K; Nelson, Karin B (2005) Perinatal arterial stroke: understanding mechanisms and outcomes. Semin Neurol 25:424-34 |
| Nelson, Karin B (2005) Neonatal encephalopathy: etiology and outcome. Dev Med Child Neurol 47:292 |
| Nelson, Karin B; Dambrosia, James M; Iovannisci, David M et al. (2005) Genetic polymorphisms and cerebral palsy in very preterm infants. Pediatr Res 57:494-9 |
| Nelson, Karin B; Lynch, John K (2004) Stroke in newborn infants. Lancet Neurol 3:150-8 |
| Grether, Judith K; Nelson, Karin B; Walsh, Eileen et al. (2003) Intrauterine exposure to infection and risk of cerebral palsy in very preterm infants. Arch Pediatr Adolesc Med 157:26-32 |
| Nelson, Karin B (2003) Can we prevent cerebral palsy? N Engl J Med 349:1765-9 |
| Lynch, John Kylan; Hirtz, Deborah G; DeVeber, Gabrielle et al. (2002) Report of the National Institute of Neurological Disorders and Stroke workshop on perinatal and childhood stroke. Pediatrics 109:116-23 |
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