Abstract

The metabolic basis of vulnerability and resilience to AD pathology remains unknown. In these analyses, we hope to address this question by examining whether brain tissue concentrations of approximately 800 metabolites are associated with severity of AD pathology in the brain and the expression of AD symptoms. If we identify such metabolites, we hope to then test whether these metabolites are also predictors of greater (or lower) risk of AD in cognitively normal older individuals. The ultimate goal of this study is to identify biologically relevant biomarkers of AD and to understand the precise molecular mechanisms mediating risk/resilience to AD pathology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG000434-01
Application #
9549304
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
Aging
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Toledo, Jon B; Arnold, Matthias; Kastenmüller, Gabi et al. (2017) Metabolic network failures in Alzheimer's disease: A biochemical road map. Alzheimers Dement 13:965-984
Thambisetty, Madhav; Casanova, Ramon; Varma, Sudhir et al. (2017) Peril beyond the winner's curse: A small sample size is the bane of biomarker discovery. Alzheimers Dement 13:606-607
Varma, V R; Varma, S; An, Y et al. (2017) Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway. Mol Psychiatry 22:13-23
Seyfried, Nicholas T; Dammer, Eric B; Swarup, Vivek et al. (2017) A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease. Cell Syst 4:60-72.e4
Snowden, Stuart G; Ebshiana, Amera A; Hye, Abdul et al. (2017) Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study. PLoS Med 14:e1002266
Wong, Matthew W; Braidy, Nady; Poljak, Anne et al. (2017) Dysregulation of lipids in Alzheimer's disease and their role as potential biomarkers. Alzheimers Dement 13:810-827
Kim, Min; Nevado-Holgado, Alejo; Whiley, Luke et al. (2016) Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease. J Alzheimers Dis :
Henderson, Benjamin W; Gentry, Erik G; Rush, Travis et al. (2016) Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-? levels in brain. J Neurochem 138:525-31
Westwood, Sarah; Leoni, Emanuela; Hye, Abdul et al. (2016) Blood-Based Biomarker Candidates of Cerebral Amyloid Using PiB PET in Non-Demented Elderly. J Alzheimers Dis 52:561-72
Hales, Chadwick M; Dammer, Eric B; Deng, Qiudong et al. (2016) Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression. Proteomics 16:3042-3053

Showing the most recent 10 out of 11 publications