Abstract

We have been interested in the relationship between oxidative stress and DJ-1, a rare cause of recessive Parkinson's disease, for several years and have focussed the relationship between oxidative stress and mitochondrial localization. In the current period, we have explored the effects of DJ-1 deficiency in the brains of mice and other species. We have found that there are distinct, evolutionarily conserved, changes in bioenergetics as a result of DJ-1 deletion. These phenomena appear to be purely in vivo events and become stronger with age. Current work is aimed at understanding the consequences of misregulation of energetics in the context of DJ-1 deficiency.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG000953-14
Application #
9147392
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
2015
Total Cost
Indirect Cost

  Institution

Name
Aging
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Hauser, David N; Mamais, Adamantios; Conti, Melissa M et al. (2017) Hexokinases link DJ-1 to the PINK1/parkin pathway. Mol Neurodegener 12:70
Hauser, David N; Primiani, Christopher T; Cookson, Mark R (2017) The Effects of Variants in the Parkin, PINK1, and DJ-1 Genes along with Evidence for their Pathogenicity. Curr Protein Pept Sci 18:702-714
Cookson, Mark R (2017) RNA-binding proteins implicated in neurodegenerative diseases. Wiley Interdiscip Rev RNA 8:
Hauser, David N; Dillman, Allissa A; Ding, Jinhui et al. (2014) Post-translational decrease in respiratory chain proteins in the Polg mutator mouse brain. PLoS One 9:e94646
Prahlad, Janani; Hauser, David N; Milkovic, Nicole M et al. (2014) Use of cysteine-reactive cross-linkers to probe conformational flexibility of human DJ-1 demonstrates that Glu18 mutations are dimers. J Neurochem 130:839-53
Cookson, Mark R (2012) Parkinsonism due to mutations in PINK1, parkin, and DJ-1 and oxidative stress and mitochondrial pathways. Cold Spring Harb Perspect Med 2:a009415
McCoy, Melissa K; Cookson, Mark R (2011) DJ-1 regulation of mitochondrial function and autophagy through oxidative stress. Autophagy 7:531-2
Hauser, David N; Cookson, Mark R (2011) Astrocytes in Parkinson's disease and DJ-1. J Neurochem 117:357-8
Thomas, Kelly Jean; McCoy, Melissa K; Blackinton, Jeff et al. (2011) DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy. Hum Mol Genet 20:40-50
Cookson, Mark R (2010) Unravelling the role of defective genes. Prog Brain Res 183:43-57

Showing the most recent 10 out of 13 publications