Abstract

Accomplishments during the year: 1. The immune response to AMA1 combined with RON2 has been studied. This work continues to expand our understanding of parasite invasion of red cells by identifying the receptors and ligands and determining the potential of these targets for vaccine development. 2. We are studying the pathway of phosphorylation by P. falciparum kinases. 3. We continue the study of the mechanism of red cell invasion by P. falciparum and P. vivax. The focus in P. vivax is on invasion of P. vivax into Duffy negative red cells. 4. We are studying the parasite encoded red cell transporter. Accomplishments during the year: 1. The immune response to AMA1 combined with RON2 has been studied. This work continues to expand our understanding of parasite invasion of red cells by identifying the receptors and ligands and determining the potential of these targets for vaccine development. 2. We are studying the pathway of phosphorylation by P. falciparum kinases. 3. We continue the study of the mechanism of red cell invasion by P. falciparum and P. vivax. The focus in P. vivax is on invasion of P. vivax into Duffy negative red cells.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAI000241-36
Application #
9560543
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
36
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Gunalan, Karthigayan; Niangaly, Amadou; Thera, Mahamadou A et al. (2018) Plasmodium vivax Infections of Duffy-Negative Erythrocytes: Historically Undetected or a Recent Adaptation? Trends Parasitol 34:420-429
Azasi, Yvonne; Lindergard, Gabriella; Ghumra, Ashfaq et al. (2018) Infected erythrocytes expressing DC13 PfEMP1 differ from recombinant proteins in EPCR-binding function. Proc Natl Acad Sci U S A 115:1063-1068
Bansal, Abhisheka; Molina-Cruz, Alvaro; Brzostowski, Joseph et al. (2018) PfCDPK1 is critical for malaria parasite gametogenesis and mosquito infection. Proc Natl Acad Sci U S A 115:774-779
Akkaya, Munir; Akkaya, Billur; Kim, Ann S et al. (2018) Toll-like receptor 9 antagonizes antibody affinity maturation. Nat Immunol 19:255-266
Arora, Gunjan; Hart, Geoffrey T; Manzella-Lapeira, Javier et al. (2018) NK cells inhibit Plasmodium falciparum growth in red blood cells via antibody-dependent cellular cytotoxicity. Elife 7:
Niangaly, Amadou; Karthigayan Gunalan; Amed Ouattara et al. (2017) Plasmodium vivax Infections over 3 Years in Duffy Blood Group Negative Malians in Bandiagara, Mali. Am J Trop Med Hyg 97:744-752
Miller, Louis H (2017) The Impact of Ken Warren's Leadership of the Rockefeller Foundation's Great Neglected Diseases Program on the Future of Malaria Research. Am J Trop Med Hyg 97:1958
Bansal, Abhisheka; Molina-Cruz, Alvaro; Brzostowski, Joseph et al. (2017) Plasmodium falciparum Calcium-Dependent Protein Kinase 2 Is Critical for Male Gametocyte Exflagellation but Not Essential for Asexual Proliferation. MBio 8:
Riggle, Brittany A; Miller, Louis H; Pierce, Susan K (2017) Do we know enough to find an adjunctive therapy for cerebral malaria in African children? F1000Res 6:2039
Sherling, Emma S; Knuepfer, Ellen; Brzostowski, Joseph A et al. (2017) The Plasmodium falciparum rhoptry protein RhopH3 plays essential roles in host cell invasion and nutrient uptake. Elife 6:

Showing the most recent 10 out of 74 publications