Abstract

The administration of intermittent cycles of interleukin-2 (IL-2) to patients with HIV infection was found to be associated with substantial and sustained increases in the number of peripheral blood CD4+ T lymphocytes. Despite these increases in the critical element of the immune system affected by HIV, IL-2 therapy was not associated with clinical benefit as defined by overall mortality and number of new AIDS-defining illnesses. CD4+ T cell increases induced by IL-2 were better maintained when IL-2 was used together with antiretroviral therapy. Interferon-alpha was found to have antiretroviral activity superior to that of AZT. This activity was transient and not associated with the development of strains of HIV resistant to Interferon-alpha.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAI000585-21
Application #
8148396
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
21
Fiscal Year
2010
Total Cost
$2,073,852
Indirect Cost

  Institution

Name
National Institute of Allergy and Infectious Diseases
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Revell, Andrew D; Wang, Dechao; Perez-Elias, Maria-Jesus et al. (2018) 2018 update to the HIV-TRePS system: the development of new computational models to predict HIV treatment outcomes, with or without a genotype, with enhanced usability for low-income settings. J Antimicrob Chemother 73:2186-2196
Di Mascio, Michele; Srinivasula, Sharat; Kim, Insook et al. (2018) Total body CD4+ T cell dynamics in treated and untreated SIV infection revealed by in vivo imaging. JCI Insight 3:
Schreiber-Stainthorp, William; Sinharay, Sanhita; Srinivasula, Sharat et al. (2018) Brain 18F-FDG PET of SIV-infected macaques after treatment interruption or initiation. J Neuroinflammation 15:207
Baker, Jason V; Sharma, Shweta; Grund, Birgit et al. (2017) Systemic Inflammation, Coagulation, and Clinical Risk in the START Trial. Open Forum Infect Dis 4:ofx262
Barski, Artem; Cuddapah, Suresh; Kartashov, Andrey V et al. (2017) Rapid Recall Ability of Memory T cells is Encoded in their Epigenome. Sci Rep 7:39785
Sui, Hongyan; Zhou, Ming; Imamichi, Hiromi et al. (2017) STING is an essential mediator of the Ku70-mediated production of IFN-?1 in response to exogenous DNA. Sci Signal 10:
Srinivasula, Sharat; Gabriel, Erin; Kim, Insook et al. (2017) CD4+ levels control the odds of induction of humoral immune responses to tracer doses of therapeutic antibodies. PLoS One 12:e0187912
Sowrirajan, Bharatwaj; Saito, Yoshiro; Poudyal, Deepak et al. (2017) Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47phox. Sci Rep 7:43441
Brooks, Kristina M; Garrett, Katy L; Kuriakose, Safia S et al. (2017) Decreased Absorption of Dolutegravir and Tenofovir Disoproxil Fumarate, But Not Emtricitabine, in an HIV-Infected Patient Following Oral and Jejunostomy-Tube Administration. Pharmacotherapy 37:e82-e89
Le Saout, Cecile; Luckey, Megan A; Villarino, Alejandro V et al. (2017) IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion. JCI Insight 2:

Showing the most recent 10 out of 65 publications