In FY 2014, we continued the investigation of the staphylococcal peptide cytolysins, phenol-soluble modulins (PSMs). Current efforts focus on the contribution of PSMs to different infection types and the role of allelic variants of PSMs in defining pathogenesis. Furthermore, we are continuing our efforts to define the mechanism of the PSM exporter with the ultimate goal of targeting the exporter for drug development. In collaboration with Dr. Fowler at Duke, we have determined that PSM production is correlated with skin infections, representing one of the very few available findings providing epidemiological evidence for the importance of PSMs in S. aureus pathogenesis. We are also emphasizing our investigation of global lineages of hospital- and community-associated MRSA strains and of the factors that define their pathogenic and epidemiological success. These endeavors are conducted predominantly with collaborators in China and Brazil.

Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
Zip Code
Zheng, Yue; He, Lei; Asiamah, Titus K et al. (2018) Colonization of medical devices by staphylococci. Environ Microbiol 20:3141-3153
He, Lei; Zheng, Hong-Xiang; Wang, Yanan et al. (2018) Detection and analysis of methicillin-resistant human-adapted sequence type 398 allows insight into community-associated methicillin-resistant Staphylococcus aureus evolution. Genome Med 10:5
Fisher, Emilie L; Otto, Michael; Cheung, Gordon Y C (2018) Basis of Virulence in Enterotoxin-Mediated Staphylococcal Food Poisoning. Front Microbiol 9:436
Jones, Dennis; Meijer, Eelco F J; Blatter, Cedric et al. (2018) Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction. Sci Transl Med 10:
Schlatterer, Katja; Beck, Christian; Hanzelmann, Dennis et al. (2018) The Mechanism behind Bacterial Lipoprotein Release: Phenol-Soluble Modulins Mediate Toll-Like Receptor 2 Activation via Extracellular Vesicle Release from Staphylococcus aureus. MBio 9:
Nakatsuji, Teruaki; Chen, Tiffany H; Butcher, Anna M et al. (2018) A commensal strain of Staphylococcus epidermidis protects against skin neoplasia. Sci Adv 4:eaao4502
Zheng, Yue; Joo, Hwang-Soo; Nair, Vinod et al. (2018) Do amyloid structures formed by Staphylococcus aureus phenol-soluble modulins have a biological function? Int J Med Microbiol 308:675-682
Cheung, Gordon Y C; Fisher, Emilie L; McCausland, Joshua W et al. (2018) Antimicrobial Peptide Resistance Mechanism Contributes to Staphylococcus aureus Infection. J Infect Dis 217:1153-1159
Blake, Kimbria J; Baral, Pankaj; Voisin, Tiphaine et al. (2018) Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314. Nat Commun 9:37
Piewngam, Pipat; Zheng, Yue; Nguyen, Thuan H et al. (2018) Pathogen elimination by probiotic Bacillus via signalling interference. Nature 562:532-537

Showing the most recent 10 out of 119 publications