In collaboration with Drs. John Robbins and Rachel Schneerson at the Laboratory of Developmental and Molecular Immunology of the NICHD, we have developed a candidate conjugate vaccine that consists of Pfs25-Pfs25 conjugates. The immune sera induced by the conjugate vaccine displayed ability to block parasite development in mosquitoes. An Investigational New Drug Application was filed with FDA, intending a Phase 1 trial to test the safety, immunogenicity, and ex-vivo transmission blocking activity in humans. In response to FDAs comment, additional animal studies were conducted to evaluate the safety in animals.

Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2011
Total Cost
$353,966
Indirect Cost
City
State
Country
Zip Code
Sagara, Issaka; Healy, Sara A; Assadou, Mahamadoun H et al. (2018) Safety and immunogenicity of Pfs25H-EPA/Alhydrogel, a transmission-blocking vaccine against Plasmodium falciparum: a randomised, double-blind, comparator-controlled, dose-escalation study in healthy Malian adults. Lancet Infect Dis 18:969-982
Nixon, Christian P; Nixon, Christina E; Michelow, Ian C et al. (2018) Antibodies to PfsEGXP, An Early Gametocyte Enriched Phosphoprotein, Predict Decreased Plasmodium falciparum Gametocyte Density In Humans. J Infect Dis :
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