In the past year, we continued work on a long-term project that aims to provide in vitro and in vivo evidence for a role of S. epidermidis phenol-soluble modulin peptides (PSMs) in the structuring and detachment of S. epidermidis biofilms. These mechanisms are believed to be crucial for the development and dissemination of staphylococcal biofilm-related infection. This work is still ongoing with a focus on in vivo aspects. In several collaborative efforts, we have investigated antimicrobial activities of S. epidermidis PSMs (with Dr. R. Gallo), quorum-sensing (luxS) dependent gene regulation in S. epidermidis (with Dr. R. Landmann), and S. epidermidis genes influencing biofilm development and biofilm-associated infection (with Dr. Q. Gao).
| Zheng, Yue; He, Lei; Asiamah, Titus K et al. (2018) Colonization of medical devices by staphylococci. Environ Microbiol 20:3141-3153 |
| Nakatsuji, Teruaki; Chen, Tiffany H; Butcher, Anna M et al. (2018) A commensal strain of Staphylococcus epidermidis protects against skin neoplasia. Sci Adv 4:eaao4502 |
| Le, Katherine Y; Park, Matthew D; Otto, Michael (2018) Immune Evasion Mechanisms of Staphylococcus epidermidis Biofilm Infection. Front Microbiol 9:359 |
| Da, Fei; Joo, Hwang-Soo; Cheung, Gordon Y C et al. (2017) Phenol-Soluble Modulin Toxins of Staphylococcus haemolyticus. Front Cell Infect Microbiol 7:206 |
| Otto, Michael (2017) Staphylococcus epidermidis: a major player in bacterial sepsis? Future Microbiol 12:1031-1033 |
| Nguyen, Thuan H; Park, Matthew D; Otto, Michael (2017) Host Response toStaphylococcus epidermidisColonization and Infections. Front Cell Infect Microbiol 7:90 |
| Qin, Li; Da, Fei; Fisher, Emilie L et al. (2017) Toxin Mediates Sepsis Caused by Methicillin-Resistant Staphylococcus epidermidis. PLoS Pathog 13:e1006153 |
| Qin, Li; McCausland, Joshua W; Cheung, Gordon Y C et al. (2016) PSM-Mec-A Virulence Determinant that Connects Transcriptional Regulation, Virulence, and Antibiotic Resistance in Staphylococci. Front Microbiol 7:1293 |
| Joo, Hwang-Soo; Fu, Chih-Iung; Otto, Michael (2016) Bacterial strategies of resistance to antimicrobial peptides. Philos Trans R Soc Lond B Biol Sci 371: |
| Li, Tianming; He, Lei; Song, Yan et al. (2016) AraC-Type Regulator Rsp Adapts Staphylococcus aureus Gene Expression to Acute Infection. Infect Immun 84:723-34 |
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