Abstract

The immune system in man is extremely complex, comprised of dozens of functionally-unique cell subsets. Each of these subsets may have a special role in the protection from viruses or other challenges to the immune system; only now are we beginning to recognize the extent of this heterogeneity and correlate the presence and functional state of these cells with clinical status of subjects. We have focused on four main topics within this broad subject: The expression of cytotoxic effector molecules; the expression profile of chemokine receptors; the functional evaluation of cytolytic T cells; and the detailed cytokine profile of antigen-specific T cells.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAI005021-18
Application #
10018363
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
18
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
National Institute of Allergy and Infectious Diseases
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Bolton, Diane L; Song, Kaimei; Tomaras, Georgia D et al. (2017) Unique cellular and humoral immunogenicity profiles generated by aerosol, intranasal, or parenteral vaccination in rhesus macaques. Vaccine 35:639-646
Jones, K; Wockner, L; Brennan, R M et al. (2016) The impact of HLA class I and EBV latency-II antigen-specific CD8(+) T cells on the pathogenesis of EBV(+) Hodgkin lymphoma. Clin Exp Immunol 183:206-20
Zurawski, Gerard; Zurawski, Sandra; Flamar, Anne-Laure et al. (2016) Targeting HIV-1 Env gp140 to LOX-1 Elicits Immune Responses in Rhesus Macaques. PLoS One 11:e0153484
Ishizuka, Andrew S; Lyke, Kirsten E; DeZure, Adam et al. (2016) Corrigendum: Protection against malaria at 1 year and immune correlates following PfSPZ vaccination. Nat Med 22:692
Ishizuka, Andrew S; Lyke, Kirsten E; DeZure, Adam et al. (2016) Protection against malaria at 1 year and immune correlates following PfSPZ vaccination. Nat Med 22:614-23
Mahnke, Yolanda D; Fletez-Brant, Kipper; Sereti, Irini et al. (2016) Reconstitution of Peripheral T Cells by Tissue-Derived CCR4+ Central Memory Cells Following HIV-1 Antiretroviral Therapy. Pathog Immun 1:260-290
Szomolay, Barbara; Liu, Jie; Brown, Paul E et al. (2016) Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors. Immunol Cell Biol 94:573-82
Roberto, Alessandra; Castagna, Luca; Zanon, Veronica et al. (2015) Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation. Blood 125:2855-64
Conlon, Kevin C; Lugli, Enrico; Welles, Hugh C et al. (2015) Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer. J Clin Oncol 33:74-82
Kibuuka, Hannah; Berkowitz, Nina M; Millard, Monica et al. (2015) Safety and immunogenicity of Ebola virus and Marburg virus glycoprotein DNA vaccines assessed separately and concomitantly in healthy Ugandan adults: a phase 1b, randomised, double-blind, placebo-controlled clinical trial. Lancet 385:1545-54

Showing the most recent 10 out of 52 publications