Abstract

Ongoing and planned studies include evaluation of populations exposed to benzene, chlorinated solvents, organochlorines, disinfection byproducts. polycyclic aromatic hydrocarbons, arsenic, formaldehyde, diesel exhaust, coal combustion products, and selected pesticides. On-going case-control studies of stomach, esophagus, brain, bladder, renal cell, thyroid, prostate and breast cancer, NHL, and benzene-induced hematotoxicity and hematologic malignancies and cohort studies of women in China and agricultural workers in the United States are evaluating a range of potential genetic risk factors and their interaction with occupational and environmental exposures. Many of these studies are also collecting tumor samples for future molecular analyses.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACP010121-19
Application #
8938224
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
19
Fiscal Year
2014
Total Cost
Indirect Cost

  Institution

Name
Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Wong, Jason Y Y; Margolis, Helene G; Machiela, Mitchell et al. (2018) Outdoor air pollution and mosaic loss of chromosome Y in older men from the Cardiovascular Health Study. Environ Int 116:239-247
Grigoryan, Hasmik; Edmands, William M B; Lan, Qing et al. (2018) Adductomic signatures of benzene exposure provide insights into cancer induction. Carcinogenesis 39:661-668
Rothman, Nathaniel; Zhang, Luoping; Smith, Martyn T et al. (2018) Formaldehyde, Hematotoxicity, and Chromosomal Changes-Response. Cancer Epidemiol Biomarkers Prev 27:120-121
Seow, Wei Jie; Matsuo, Keitaro; Hsiung, Chao Agnes et al. (2017) Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations. Hum Mol Genet 26:454-465
Wong, Jason Y Y; Hu, Wei; Downward, George S et al. (2017) Personal exposure to fine particulate matter and benzo[a]pyrene from indoor air pollution and leukocyte mitochondrial DNA copy number in rural China. Carcinogenesis 38:893-899
GBD 2015 Healthcare Access and Quality Collaborators. Electronic address: cjlm@uw.edu; GBD 2015 Healthcare Access and Quality Collaborators (2017) Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: a novel analysis from the Global Burden of Disease Study 2015. Lancet 390:231-266
Rothman, Nathaniel; Lan, Qing; Smith, Martyn T et al. (2017) Response to letter to the editor of Carcinogenesis by Pira et al., 2017. Carcinogenesis 38:1253-1255
Wong, Jason Y; Bassig, Bryan A; Vermeulen, Roel et al. (2017) Sleep Duration across the Adult Lifecourse and Risk of Lung Cancer Mortality: A Cohort Study in Xuanwei, China. Cancer Prev Res (Phila) 10:327-336
Lu, Sixin S; Grigoryan, Hasmik; Edmands, William M B et al. (2017) Profiling the Serum Albumin Cys34 Adductome of Solid Fuel Users in Xuanwei and Fuyuan, China. Environ Sci Technol 51:46-57
Seow, Wei Jie; Lan, Qing (2016) Domestic incense use and lung cancer in Asia: a review. Rev Environ Health 31:155-8

Showing the most recent 10 out of 74 publications