Abstract

Infection, immune disturbances, and inflammation overlap in the ways that they damage tissues and promote development of cancer. Some studies in this project address the role of specific infections in cancer, including hepatitis C virus, Epstein Barr virus, and malaria in non-Hodgkin lymphoma;Helicobacter pylori in gastric cancer;Chlamydia pneumoniae in lung cancer;and human papillomavirus in penile cancer. Increasingly, it is recognized that microbial diversity (i.e., the microbiome) may play a role in influencing the tissue environment. Other studies examine how general disturbances of immunity may also facilitate development of cancer, such as occurs in solid organ transplant recipients or end stage renal disease. Finally, the project also includes studies to elucidate the role of inflammation as a pathway to cancer, such as caused by chronic infection or autoimmune diseases. The studies are human population-based. Some studies use molecular markers, such as gene markers, serum or tissue markers of infection, and cytokine levels indicating inflammation. Other studies evaluate human genetic polymorphisms that may affect inflammation and immunity and thereby modulate cancer risk..

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACP010150-10
Application #
7981279
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2009
Total Cost
$1,358,845
Indirect Cost

  Institution

Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Mahale, Parag; Engels, Eric A; Coghill, Anna E et al. (2018) Cancer Risk in Older Persons Living With Human Immunodeficiency Virus Infection in the United States. Clin Infect Dis 67:50-57
Shiels, Meredith S; Freedman, Neal D; Thomas, David et al. (2018) Trends in U.S. Drug Overdose Deaths in Non-Hispanic Black, Hispanic, and Non-Hispanic White Persons, 2000-2015. Ann Intern Med 168:453-455
Altekruse, Sean F; Shiels, Meredith S; Modur, Sharada P et al. (2018) Cancer burden attributable to cigarette smoking among HIV-infected people in North America. AIDS 32:513-521
Mahale, Parag; Shiels, Meredith S; Lynch, Charles F et al. (2018) Incidence and outcomes of primary central nervous system lymphoma in solid organ transplant recipients. Am J Transplant 18:453-461
Gupta, Gaurav; Kuppachi, Sarat; Kalil, Roberto S et al. (2018) Treatment for presumed BK polyomavirus nephropathy and risk of urinary tract cancers among kidney transplant recipients in the United States. Am J Transplant 18:245-252
Shiels, Meredith S; Islam, Jessica Y; Rosenberg, Philip S et al. (2018) Projected Cancer Incidence Rates and Burden of Incident Cancer Cases in HIV-Infected Adults in the United States Through 2030. Ann Intern Med 168:866-873
Shiels, Meredith S; Kirk, Gregory D; Drummond, M Bradley et al. (2018) HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D. J Infect Dis 217:413-417
Colón-López, Vivian; Shiels, Meredith S; Machin, Mark et al. (2018) Anal Cancer Risk Among People With HIV Infection in the United States. J Clin Oncol 36:68-75
Rabkin, Charles S; Goedert, James J (2017) Chronic Hepatitis and Non-Hodgkin Lymphoma Among People With HIV: Implications for Screening, Treatment, and Prevention. Ann Intern Med 166:69-70
Yanik, Elizabeth L; Pfeiffer, Ruth M; Freedman, D Michal et al. (2017) Spectrum of Immune-Related Conditions Associated with Risk of Keratinocyte Cancers among Elderly Adults in the United States. Cancer Epidemiol Biomarkers Prev 26:998-1007

Showing the most recent 10 out of 155 publications