Abstract

To help meet the Challenge Goal of eliminating suffering and death from cancer by 2015, the NCI must capitalize on the extraordinary momentum generated by advances in human genetic research. The sequencing of the human genome and the annotation of common variations, together with new technologies for analyzing single nucleotide polymorphisms (SNPs), have provided the tools for investigators to actively search for inherited variants in genes that can increase or modify cancer risk. The C-GEMS proposal will use the latest genomic technologies to perform dense whole genome scans to identify and validate susceptibility genes in the induction and progression of breast and prostate cancer, and clarify gene-gene and gene-environment interactions. This work will provide new insights into mechanisms of carcinogenesis, and point the way to novel strategies for meeting the 2015 Challenge Goal by accelerating the prevention, early detection, and treatment of cancer.Prostate cancer, lung cancer, bladder cancer, breast cancer, colorectal cancer, kidney cancer, non-Hodgkin's lymphoma (NHL), ovarian cancer, brain tumors, and endometrial cancer are the main focus of current and planned replication studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACP010187-09
Application #
8763635
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
2013
Total Cost
$186,238
Indirect Cost

  Institution

Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Figueroa, Jonine D; Middlebrooks, Candace D; Banday, A Rouf et al. (2016) Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry. Hum Mol Genet 25:1203-14
Figueroa, Jonine D; Koutros, Stella; Colt, Joanne S et al. (2015) Modification of Occupational Exposures on Bladder Cancer Risk by Common Genetic Polymorphisms. J Natl Cancer Inst 107:
Matsuda, Koichi; Takahashi, Atsushi; Middlebrooks, Candace D et al. (2015) Genome-wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population. Hum Mol Genet 24:1177-84
Figueroa, Jonine D; Ye, Yuanqing; Siddiq, Afshan et al. (2014) Genome-wide association study identifies multiple loci associated with bladder cancer risk. Hum Mol Genet 23:1387-98
Figueroa, Jonine D; Han, Summer S; Garcia-Closas, Montserrat et al. (2014) Genome-wide interaction study of smoking and bladder cancer risk. Carcinogenesis 35:1737-44
Salas, Lucas A; Cantor, Kenneth P; Tardon, Adonina et al. (2013) Biological and statistical approaches for modeling exposure to specific trihalomethanes and bladder cancer risk. Am J Epidemiol 178:652-60
Han, Summer S; Yeager, Meredith; Moore, Lee E et al. (2012) The chromosome 2p21 region harbors a complex genetic architecture for association with risk for renal cell carcinoma. Hum Mol Genet 21:1190-200
Cote, Michele L; Colt, Joanne S; Schwartz, Kendra L et al. (2012) Cigarette smoking and renal cell carcinoma risk among black and white Americans: effect modification by hypertension and obesity. Cancer Epidemiol Biomarkers Prev 21:770-9
Menashe, Idan; Figueroa, Jonine D; Garcia-Closas, Montserrat et al. (2012) Large-scale pathway-based analysis of bladder cancer genome-wide association data from five studies of European background. PLoS One 7:e29396
Chanock, Stephen (2009) High marks for GWAS. Nat Genet 41:765-6

Showing the most recent 10 out of 11 publications