Abstract

High rates of relapse to drug use after prolonged drug-free periods characterize the behavior of people addicted to opioid and psychostimulant drugs. The behavioral and neurochemical events that contribute to these high relapse rates, however, are not well understood. Relapse can be induced in human subjects and laboratory animals by re-exposure to the drug previously used or re-exposure to environmental cues paired with drug self-administration. We are using different animal models of relapse to study brain systems and neurotransmitters involved in relapse induced by these stimuli in rats with a history of opioid (heroin, oxycodone, fentanyl) and psychostimulant (cocaine, methamphetamine) self-administration.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIADA000434-20
Application #
9995333
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
20
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Lê, A D; Funk, Douglas; Coen, Kathleen et al. (2018) Role of ?-Opioid Receptors in the Bed Nucleus of Stria Terminalis in Reinstatement of Alcohol Seeking. Neuropsychopharmacology 43:838-850
Marchant, Nathan J; Campbell, Erin J; Kaganovsky, Konstantin (2018) Punishment of alcohol-reinforced responding in alcohol preferring P rats reveals a bimodal population: Implications for models of compulsive drug seeking. Prog Neuropsychopharmacol Biol Psychiatry 87:68-77
Xue, Yan-Xue; Deng, Jia-Hui; Chen, Ya-Yun et al. (2017) Effect of Selective Inhibition of Reactivated Nicotine-Associated Memories With Propranolol on Nicotine Craving. JAMA Psychiatry 74:224-232
Fredriksson, Ida; Adhikary, Sweta; Steensland, Pia et al. (2017) Prior Exposure to Alcohol Has No Effect on Cocaine Self-Administration and Relapse in Rats: Evidence from a Rat Model that Does Not Support the Gateway Hypothesis. Neuropsychopharmacology 42:1001-1011
Xue, Yan-Xue; Chen, Ya-Yun; Zhang, Li-Bo et al. (2017) Selective Inhibition of Amygdala Neuronal Ensembles Encoding Nicotine-Associated Memories Inhibits Nicotine Preference and Relapse. Biol Psychiatry 82:781-793
Golden, S A; Aleyasin, H; Heins, R et al. (2017) Persistent conditioned place preference to aggression experience in adult male sexually-experienced CD-1 mice. Genes Brain Behav 16:44-55
Golden, Sam A; Heins, Conor; Venniro, Marco et al. (2017) Compulsive Addiction-like Aggressive Behavior in Mice. Biol Psychiatry 82:239-248
Pelloux, Yann; K Hoots, Jennifer; Cifani, Carlo et al. (2017) Context-induced relapse to cocaine seeking after punishment-imposed abstinence is associated with activation of cortical and subcortical brain regions. Addict Biol :
Caprioli, Daniele; Venniro, Marco; Zhang, Michelle et al. (2017) Role of Dorsomedial Striatum Neuronal Ensembles in Incubation of Methamphetamine Craving after Voluntary Abstinence. J Neurosci 37:1014-1027
Adhikary, Sweta; Caprioli, Daniele; Venniro, Marco et al. (2017) Incubation of extinction responding and cue-induced reinstatement, but not context- or drug priming-induced reinstatement, after withdrawal from methamphetamine. Addict Biol 22:977-990

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