Abstract

We continue to develop mathematical models of human metabolism and have conducted several validation studies using a variety of published data on the metabolic responses to overfeeding, underfeeding, and isocaloric changes in dietary macronutrients. Our models have been deployed as an online body weight simulator at http://bwsimulator.niddk.nih.gov to help design prospective studies as well as plan and track clinical weight management programs. Our models are being applied to a variety of problems, from calculating the relationship between human weight change and food intake to calculating changes of free-living energy intake using frequent body weight measurements. We have also used our models to help address policy issues such as the likely effect of soda taxes on US obesity prevalence.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIADK013036-07
Application #
8741345
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2013
Total Cost
$338,364
Indirect Cost

  Institution

Name
National Institute of Diabetes and Digestive and Kidney Diseases
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Guo, Juen; Brager, Danielle C; Hall, Kevin D (2018) Simulating long-term human weight-loss dynamics in response to calorie restriction. Am J Clin Nutr 107:558-565
Hall, Kevin D; Kahan, Scott (2018) Maintenance of Lost Weight and Long-Term Management of Obesity. Med Clin North Am 102:183-197
Hall, Kevin D; Schoeller, Dale A; Brown, Andrew W (2018) Reducing Calories to Lose Weight. JAMA 319:2336-2337
Hall, Kevin D; Sanghvi, Arjun; Göbel, Britta (2017) Proportional Feedback Control of Energy Intake During Obesity Pharmacotherapy. Obesity (Silver Spring) 25:2088-2091
Hall, Kevin D; Guo, Juen (2017) Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition. Gastroenterology 152:1718-1727.e3
Katan, Martijn B; de Ruyter, Janne C; Kuijper, Lothar D J et al. (2016) Impact of Masked Replacement of Sugar-Sweetened with Sugar-Free Beverages on Body Weight Increases with Initial BMI: Secondary Analysis of Data from an 18 Month Double-Blind Trial in Children. PLoS One 11:e0159771
MacLeod, Erin L; Hall, Kevin D; McGuire, Peter J (2016) Computational modeling to predict nitrogen balance during acute metabolic decompensation in patients with urea cycle disorders. J Inherit Metab Dis 39:17-24
Polidori, David; Sanghvi, Arjun; Seeley, Randy J et al. (2016) How Strongly Does Appetite Counter Weight Loss? Quantification of the Feedback Control of Human Energy Intake. Obesity (Silver Spring) 24:2289-2295
Freedhoff, Yoni; Hall, Kevin D (2016) Weight loss diet studies: we need help not hype. Lancet 388:849-51
Vandevijvere, Stefanie; Chow, Carson C; Hall, Kevin D et al. (2015) Increased food energy supply as a major driver of the obesity epidemic: a global analysis. Bull World Health Organ 93:446-56

Showing the most recent 10 out of 45 publications