Abstract

We created used a mathematical model of mouse energy metabolism that provides a quantitative framework for investigating energy balance relationships. We applied this model to investigate body weight regulation of mice subjected to various ad libitum diets with and without running wheel access. We also investigated the role of striatal dopamine signaling on food intake and physical activity behavior and we are studied how weight gain and loss on various diets leads to changes in brain dopamine signaling.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIADK013038-12
Application #
9780127
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst Diabetes/Digst/Kidney
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

O'Neal, Timothy J; Friend, Danielle M; Guo, Juen et al. (2017) Increases in Physical Activity Result in Diminishing Increments in Daily Energy Expenditure in Mice. Curr Biol 27:423-430
Selimkhanov, J; Thompson, W C; Guo, J et al. (2017) A quantitative analysis of statistical power identifies obesity end points for improved in vivo preclinical study design. Int J Obes (Lond) 41:1306-1309
Friend, Danielle M; Devarakonda, Kavya; O'Neal, Timothy J et al. (2017) Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity. Cell Metab 25:312-321
Bond, Nichole D; Guo, Juen; Hall, Kevin D et al. (2016) Modeling Energy Dynamics in Mice with Skeletal Muscle Hypertrophy Fed High Calorie Diets. Int J Biol Sci 12:617-30
Devarakonda, Kavya; Nguyen, Katrina P; Kravitz, Alexxai V (2015) ROBucket: A low cost operant chamber based on the Arduino microcontroller. Behav Res Methods :
Hall, Kevin D (2012) Metabolism of mice and men: mathematical modeling of body weight dynamics. Curr Opin Clin Nutr Metab Care 15:418-23
Guo, Juen; Hall, Kevin D (2011) Predicting changes of body weight, body fat, energy expenditure and metabolic fuel selection in C57BL/6 mice. PLoS One 6:e15961
Guo, Juen; Hall, Kevin D (2011) Challenges of indirect calorimetry in mice. Am J Physiol Regul Integr Comp Physiol 300:R780; author reply R781-2
Hall, Kevin D (2010) Mathematical modelling of energy expenditure during tissue deposition. Br J Nutr 104:4-7
Jo, Junghyo; Guo, Juen; Liu, Teresa et al. (2010) Hypertrophy-driven adipocyte death overwhelms recruitment under prolonged weight gain. Biophys J 99:3535-44

Showing the most recent 10 out of 14 publications