1) Continuing our work on exosomes as a source of biomarkers, in collaboration with the Knepper group we found that Tamm-Horsfall protein complicates the purification of exosomes from humans and animals. We continue to work on methods to improve recovery of exosomal protein and miRNA in light of these observations. 2) Serum creatinine is used clinically as a biomarker for acute kidney injury, and in collaboration with the Schnermann/Briggs group we further demonstrate that in mice the extent of tubular secretion confounds the use of serum creatinine. We continue to work on alternatives to serum creatinine such as serum cystatin C.
| Wolfinger, Russell D; Beedanagari, Sudheer; Boitier, Eric et al. (2018) Two approaches for estimating the lower limit of quantitation (LLOQ) of microRNA levels assayed as exploratory biomarkers by RT-qPCR. BMC Biotechnol 18:6 |
| Street, Jonathan M; Koritzinsky, Erik H; Glispie, Deonna M et al. (2017) Urine Exosome Isolation and Characterization. Methods Mol Biol 1641:413-423 |
| Koritzinsky, Erik H; Street, Jonathan M; Star, Robert A et al. (2017) Cover Image, Volume 232, Number 7, July 2017. J Cell Physiol 232:i |
| Cai, Yan; Xu, Ming-Jiang; Koritzinsky, Erik H et al. (2017) Mitochondrial DNA-enriched microparticles promote acute-on-chronic alcoholic neutrophilia and hepatotoxicity. JCI Insight 2: |
| Street, J M; Koritzinsky, E H; Glispie, D M et al. (2017) Urine Exosomes: An Emerging Trove of Biomarkers. Adv Clin Chem 78:103-122 |
| Koritzinsky, Erik H; Street, Jonathan M; Star, Robert A et al. (2017) Quantification of Exosomes. J Cell Physiol 232:1587-1590 |
| Bavendam, Tamara G; Norton, Jenna M; Kirkali, Ziya et al. (2016) Advancing a Comprehensive Approach to the Study of Lower Urinary Tract Symptoms. J Urol 196:1342-1349 |
| Askenazi, David J; Morgan, Catherine; Goldstein, Stuart L et al. (2016) Strategies to improve the understanding of long-term renal consequences after neonatal acute kidney injury. Pediatr Res 79:502-8 |
| Souza, Ana Carolina P; Bocharov, Alexander V; Baranova, Irina N et al. (2016) Antagonism of scavenger receptor CD36 by 5A peptide prevents chronic kidney disease progression in mice independent of blood pressure regulation. Kidney Int 89:809-22 |
| Thompson, Karol L; Boitier, Eric; Chen, Tao et al. (2016) Absolute Measurement of Cardiac Injury-Induced microRNAs in Biofluids across Multiple Test Sites. Toxicol Sci 154:115-125 |
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