The sampling frame for the Study is New York State (NYS), exclusive of New York City. The Study, which began September 4, 2007, is designed to use a population-based sampling strategy to recruit and compare the development of a matched-exposure cohort of infants, i.e., infants identified from pregnancies conceived with the help of infertility treatment, as noted in the NYS Perinatal Data System, and infants who were conceived without such therapies. The infertility treatment exposure is the basis for the sampling because of its relative rarity. For the primary cohort, infants identified as having been conceived by infertility treatment (exposed) were enrolled as participants at 3-5 months of age (gestation-corrected, if necessary) and followed longitudinally until age 36 months (3 years), along with a cohort unexposed infants, frequency-matched for residence within a NYS Regional Perinatal Network and plurality of birth. All co-twins of Study participants were enrolled simultaneously and either their outcomes noted (e.g., stillbirth, neonatal mortality) or they are being followed (secondary cohort) on the same schedule as Study participants, although the co-twins will not be considered as part of the primary cohort. Higher order multiples (triplets, quadruplets) were also enrolled and followed on the same schedule, regardless of exposure status. The recruitment window extended from September 17, 2008 (first mailing) through December 17, 2010 (final consent received), representing an approximate 2-year period of births. Cohorts of over 6,300 infants representing 5,147 individual mothers were enrolled. Parents of infants born in NYS are asked to participate in the Study for three years by: (a.) completing an initial questionnaire about the pregnancy, including, for example, confirmation of infertility treatment, time-to-pregnancy, infant feeding, and other demographic and socioeconomic factors (i.e., maternal education, occupation) and confounders associated with motor and social development;(b.) completing a standardized screening instrument that addresses their childs motor and social development at chronologic or gestation-corrected ages 4, 8, 12, 16, 20, 24, 30, and 36 months;and (c.) providing information on the child's growth and medical history (e.g., illnesses, diagnoses of birth defects, major impairments). Information on growth and medical history are assembled in journal format from physicians examination data. Records will be linked to other pertinent health records (e.g., early intervention programs, WIC, birth defect or cancer registries). Several additional components have been added: (a.) a detailed ART history by linking with the Society for Assisted Reproductive Technology (SART) cycle-based database;(b.) the acquisition of residual blood specimens left over from mandatory neonatal screening and laboratory testing for biomarkers and environmental exposures. The blood specimens are owned and archived at the Wadsworth Center Laboratories (New York State Department of Health), and (c.) plans for the administration of a standardized assessment for diagnosing developmental disabilities using a battery of empirically validated and reliable instruments around 36 months of age for all infants and children who fail any of the neurodevelopmental screens.
| Ghassabian, Akhgar; Sundaram, Rajeshwari; Chahal, Nikhita et al. (2018) Concentrations of immune marker in newborn dried blood spots and early childhood development: Results from the Upstate KIDS Study. Paediatr Perinat Epidemiol 32:337-345 |
| Buck Louis, Germaine M; Bell, Erin; Xie, Yunlong et al. (2018) Parental health status and infant outcomes: Upstate KIDS Study. Fertil Steril 109:315-323 |
| Yeung, E H; Sundaram, R; Xie, Y et al. (2018) Newborn adipokines and early childhood growth. Pediatr Obes 13:505-513 |
| Bell, Griffith A; Sundaram, Rajeshwari; Mumford, Sunni L et al. (2018) Maternal polycystic ovarian syndrome and early offspring development. Hum Reprod 33:1307-1315 |
| Park, Hyojun; Sundaram, Rajeshwari; Gilman, Stephen E et al. (2018) Timing of Maternal Depression and Sex-Specific Child Growth, the Upstate KIDS Study. Obesity (Silver Spring) 26:160-166 |
| Bell, Griffith A; Sundaram, Rajeshwari; Mumford, Sunni L et al. (2018) Maternal polycystic ovarian syndrome and offspring growth: the Upstate KIDS Study. J Epidemiol Community Health 72:852-855 |
| Vollet, K; Ghassabian, A; Sundaram, R et al. (2017) Prenatal fish oil supplementation and early childhood development in the Upstate KIDS Study. J Dev Orig Health Dis 8:465-473 |
| Chahal, Nikhita; McLain, Alexander C; Ghassabian, Akhgar et al. (2017) Maternal Smoking and Newborn Cytokine and Immunoglobulin Levels. Nicotine Tob Res 19:789-796 |
| Robledo, Candace A; Yeung, Edwina H; Mendola, Pauline et al. (2017) Examining the Prevalence Rates of Preexisting Maternal Medical Conditions and Pregnancy Complications by Source: Evidence to Inform Maternal and Child Research. Matern Child Health J 21:852-862 |
| Broadney, M M; Chahal, N; Michels, K A et al. (2017) Impact of parental obesity on neonatal markers of inflammation and immune response. Int J Obes (Lond) 41:30-37 |
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