Abstract

The speciality field of laboratory animal medicine and care covers a diverse array of responsibilities. The Rocky Mountain Veterinary Branch (RMVB) staff may encounter unusual clinical cases and emerging murine infectious diseases during their normal work duties that are conducive to study. The construction and management of facilities for human emerging diseases and potential bioterrorism agent research also results in unique experiences. Investigation of these observations and experiences contributes to advancing the body of knowledge within the laboratory animal field. The diligent RMVB staff provide the support necessary for DIR investigators to conduct cutting edge research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Animal Research Infrastructure Intramural Research (ZIG)
Project #
1ZIGAI001048-05
Application #
8556190
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2012
Total Cost
$8,385,737
Indirect Cost

  Institution

Name
National Institute of Allergy and Infectious Diseases
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

de Wit, Emmie; Siegers, Jurre Y; Cronin, Jacqueline M et al. (2018) 1918 H1N1 Influenza Virus Replicates and Induces Proinflammatory Cytokine Responses in Extrarespiratory Tissues of Ferrets. J Infect Dis 217:1237-1246
Zivcec, Marko; Safronetz, David; Scott, Dana P et al. (2018) Nucleocapsid protein-based vaccine provides protection in mice against lethal Crimean-Congo hemorrhagic fever virus challenge. PLoS Negl Trop Dis 12:e0006628
Rosenke, Kyle; Bounds, Callie E; Hanley, Patrick W et al. (2018) Human Polyclonal Antibodies Produced by Transchromosomal Cattle Provide Partial Protection Against Lethal Zaire Ebolavirus Challenge in Rhesus Macaques. J Infect Dis :
Rosenke, Kyle; Feldmann, Heinz; Westover, Jonna B et al. (2018) Use of Favipiravir to Treat Lassa Virus Infection in Macaques. Emerg Infect Dis 24:1696-1699
Marzi, Andrea; Chadinah, Spencer; Haddock, Elaine et al. (2018) Recently Identified Mutations in the Ebola Virus-Makona Genome Do Not Alter Pathogenicity in Animal Models. Cell Rep 23:1806-1816
Prescott, Joseph; Falzarano, Darryl; de Wit, Emmie et al. (2018) Pathogenicity and Viral Shedding of MERS-CoV in Immunocompromised Rhesus Macaques. Front Immunol 9:205
Domi, Arban; Feldmann, Friederike; Basu, Rahul et al. (2018) A Single Dose of Modified Vaccinia Ankara expressing Ebola Virus Like Particles Protects Nonhuman Primates from Lethal Ebola Virus Challenge. Sci Rep 8:864
de Wit, Emmie; Feldmann, Friederike; Okumura, Atsushi et al. (2018) Prophylactic and therapeutic efficacy of mAb treatment against MERS-CoV in common marmosets. Antiviral Res 156:64-71
Staquicini, D I; D'Angelo, S; Ferrara, F et al. (2018) Therapeutic targeting of membrane-associated GRP78 in leukemia and lymphoma: preclinical efficacy in vitro and formal toxicity study of BMTP-78 in rodents and primates. Pharmacogenomics J 18:436-443
Haddock, Elaine; Feldmann, Friederike; Hawman, David W et al. (2018) A cynomolgus macaque model for Crimean-Congo haemorrhagic fever. Nat Microbiol 3:556-562

Showing the most recent 10 out of 59 publications