The project serves to coordinate the doctoral research training and the university-NIH interface. The project provides trainees with molecular and comparative pathology educational content suitable for graduate credit at partnership universities. Staff within the Molecular Pathology Unit have a significant responsibility for training and mentoring trainees. Trainees undertake pre-dissertation research within the molecular pathology unit for which they receive university graduate course credit. The veterinary pathologists undertaking research training integrate pathology into the range of intramural research. Training for integrating the veterinary pathologist into the laboratory results in fulfillment of the training programs vision of vertically integrated pathologist-investigator, working in partnership as research team member from discovery to research translation. The educational infrastructure within the training consortium includes university collaboration and builds upon an interdisciplinary orientation to problems in biomedical science. Program and trainee accomplishments for fiscal year 2009 include: Accomplishments 1. Recruited 3 veterinarians to initiate Graduate Partnership Program training - one at Purdue University, West Layfayette, IN and two at North Carolina State University, Raleigh, NC. 2. Program trainees authored or co-authored 10 peer-reviewed scientific journal articles : 7 research, and 3 clinical articles published in journals including: Cancer, Cancer Research, Cell Stem Cell, JAVMA, Journal of Experimental Medicine, Molecular Endocrinology, PLoS ONE, Veterinary Pathology 3. Two Young Investigator Awards 2009-2010. 4. Six veterinary students trained during summer internships or clerkships within the training program. 2 of 6 won poster presentation awards at the National Veterinary Scholars Symposium, August 7, 2010, Athens, GA

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Animal Research Infrastructure Intramural Research (ZIG)
Project #
1ZIGBC010931-03
Application #
8158463
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2010
Total Cost
$950,585
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code
Martin, P L; Yin, J-J; Seng, V et al. (2017) Androgen deprivation leads to increased carbohydrate metabolism and hexokinase 2-mediated survival in Pten/Tp53-deficient prostate cancer. Oncogene 36:525-533
LeBlanc, Amy K; Mazcko, Christina; Brown, Diane E et al. (2016) Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients. Neuro Oncol 18:1209-18
Wei, Bih-Rong; Michael, Helen T; Halsey, Charles H C et al. (2016) Synergistic targeted inhibition of MEK and dual PI3K/mTOR diminishes viability and inhibits tumor growth of canine melanoma underscoring its utility as a preclinical model for human mucosal melanoma. Pigment Cell Melanoma Res :
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Zhang, Shuling; Pruitt, Margaret; Tran, Dena et al. (2013) B cell-specific deficiencies in mTOR limit humoral immune responses. J Immunol 191:1692-703
Cramer, Sarah D; Campbell, Gregory A; Gray, Charles W et al. (2012) Pathology in practice. Brain neoplasm. J Am Vet Med Assoc 240:47-9
Wei, Bih-Rong; Simpson, R Mark; Johann, Donald J et al. (2012) Proteomic profiling of H-Ras-G12V induced hypertrophic cardiomyopathy in transgenic mice using comparative LC-MS analysis of thin fresh-frozen tissue sections. J Proteome Res 11:1561-70
Sharkey, L C; Simpson, R M; Wellman, M L et al. (2012) The value of biomedical research training for veterinary anatomic and clinical pathologists. Vet Pathol 49:581-5

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