This proposal will demonstrate a software infrastructure specialized to study of cerbrovasculature. The problem is of great societal importance and is typical of a number of multiscale multiphysics problems encountered in multiple branches of science. The investigators will focus in this project on: ? Scalable Continuum Models using their highly accurate hp adaptive spectral element code NEKTAR, ? Stochastic Continuum/Atomistic Modeling (LAMMPS-DPD); ? Multi-Level Parallelism, and, finally an effort to make computing across multiple grids by doing a pilot of TeraGrid-DEISA Grid Computing.