9527192 Taylor The Nanomanupulator (nM) project will investigate the most powerful and efficient systems, methods and algorithm for applying the high-performance graphics supercomputer, Pixel-Flow, to the real-time control of scientific instrumentation. The nM system provides an intuitive interface to scanning probe microscopes (SPMs), allowing scientists from a variety if disciplines to examine and manipulate nanometer-scale structures. The nM displays a high quality rendering of the surface being scanned as the data arrives in real time. using force-feedback controls, the scientists can feel the surface representation to enhance understanding of surface properties and can modify the surface directly. Important proof-of-concept studies have shown that the nM greatly increases productivity by acting as a translator between controlled. This project will study issues which will made the nM a more powerful and accessible tool for the scientific community.