This grant in the Analytical and Surface Chemistry Program is in the area of mass spectrometry of biomolecules. Professor Lebrilla and his students will use an external source Fourier transform mass spectrometer, FTMS, to measure gas-phase basicities of protonated biomolecules. Semi-empirical molecular orbital calculations will be used to determine the sites of protonation in oligosaccharides. In addition, hydrogen/deuterium exchange reactions with chiral alcohols will be used to determine the exact configuration of different exchange sites on the oligosaccharides. The goal of the proposed research is to increase our understanding of intramolecular interactions and proton migration pathways in gas-phase biomolecules. %%% Professor Lebrilla proposes to use Fourier transform mass spectrometry to elucidate the structure of gas-phase biomolecules. The research involves mass spectrometry, molecular orbital calculations and hydrogen/deuterium exchange reactions.

Agency
National Science Foundation (NSF)
Institute
Division of Chemistry (CHE)
Application #
9310092
Program Officer
R. Kenneth Marcus
Project Start
Project End
Budget Start
1993-07-01
Budget End
1997-03-31
Support Year
Fiscal Year
1993
Total Cost
$217,000
Indirect Cost
Name
University of California Davis
Department
Type
DUNS #
City
Davis
State
CA
Country
United States
Zip Code
95618