The focus of this research is the application to organic synthesis of organosilicon compounds which utilize more than one of the bonds to silicon, especially organosilicon compounds with a protected internal nucleophile. The scope, as well as the potential use of rearrangement and cleavage reactions induced by a gamma-oxidopropyl group on silicon will be investigated, especially possible applications to asymmetric synthesis. The effect of silicon groups, compared to hydrogen, on the reactivity of ring opening reactions of expoxides will be studied. With this award, the Synthetic Organic Program is supporting the research of Dr. Paul F. and Anne M. Hudrlick of the Department of Chemistry at Howard University. The Hudrliks will focus their work on the utility of organosilicon compounds as intermediates in organic synthesis to develop new reactions of general applicability.

Agency
National Science Foundation (NSF)
Institute
Division of Chemistry (CHE)
Application #
9505465
Program Officer
Kenneth M. Doxsee
Project Start
Project End
Budget Start
1995-07-15
Budget End
1999-06-30
Support Year
Fiscal Year
1995
Total Cost
$290,000
Indirect Cost
Name
Howard University
Department
Type
DUNS #
City
Washington
State
DC
Country
United States
Zip Code
20059