This is an experimental/computer simulation study of the mechanisms of strengthening in austenitic stainless steels by addition of nitrogen. Mechanical testing is performed at temperatures between 4 and 900 degrees Kelvin on single crystal specimens containing controlled amounts of nitrogen. Slip behavior is examined by electron microscopy. Results are correlated with a flow stress model developed on thermodynamic principles that predicts flow stress, including thermal activation of planar slip. This research improves our base for the development of nitrogen-containing steels. Nitrogen strengthened steels may lead to low cost, high strength alternatives to our present steels. Such steels can exhibit excellent combinations of strength and toughness.