Dr. Low will attempt to map out the portion of the cholinergic receptor molecule which binds to a toxin. The technique involves forming covalent bonds between the toxin and identified peptide sequences of the receptors, using a photoreactive group inserted in the peptides. This approach is new and if successful, can be used to probe the properties of other receptor molecules.

Agency
National Science Foundation (NSF)
Institute
Division of Integrative Organismal Systems (IOS)
Type
Standard Grant (Standard)
Application #
9002702
Program Officer
Stacy Springer
Project Start
Project End
Budget Start
1990-01-01
Budget End
1991-05-31
Support Year
Fiscal Year
1990
Total Cost
$29,484
Indirect Cost
Name
Columbia University
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10027